Background: Cytokeratin 18 (CK-18) is a cytoskeleton protein of epithelial cells which are released into the circulation during necrotic or apoptotic cell death. M30 detects caspase-cleaved neo-epitope of CK-18; whereas M 65 measures whole length intact protein. We aimed to evaluate the prognostic significance of serum M65 and M30 levels in patients with gastric carcinoma.
Methods: Thirty eight patients with advanced disease were included in the study. Thirty-two healthy people were chosen as control group. Serum M65 and M30 levels were measured by quantitative ELISA method.
Results: Serum M65 levels were found significantly elevated in patients compared to control group (385.7+/-280.6 vs. 200.2+/-164.5, p=0.002). Serum M30 levels were significantly increased in patients compared to the control group (204.6+/-245 vs. 106.5+/-17.5, p=0.03). Patients with metastatic disease had significantly higher levels of serum M30 compared to patients with locally advanced disease (267.1+/-296.1 vs. 102.3+/-53.2, p=0.03). Serum M30 and M65 levels were evaluated in respect to survival. Best cut-off value for the prediction of death for M30 antigen level was 83.8U/L. Patients with higher M30 levels had significantly shorter median survival compared to patients' lower serum M30 levels. However, there was no impact of serum M65 levels on survival. Serum M30 levels and clinical stage were found as the strongest variables with independent prognostic value for overall survival.
Discussion: These results suggest that serum M65 and M30 levels were elevated in patients with advanced gastric carcinoma patients. Serum M30 levels can be helpful to predict tumor load and also survival.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2010.03.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A new Mediterranean Lifestyle Pyramid for children and youth: a critical lifestyle tool for preventing obesity and associated cardiometabolic diseases in a sustainable context.
Adv Nutr
January 2025
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona (UB), Barcelona, Spain; Institut de Recerca en Nutrició i Seguretat Alimentaria (INSA-UB). University of Barcelona, Barcelona, Spain; Fundación Dieta Mediterránea, Barcelona, Spain. Electronic address:
Cardiovascular risk factors begin in childhood and track into adulthood, increasing the possibility of impaired cardiometabolic health. Adopting healthy dietary patterns can help curb childhood obesity, a worrisome epidemic problem at present. In the era of personalized nutrition, dietary recommendations should be adapted to different stages of life, including children (older than 3 years) and adolescents.
View Article and Find Full Text PDFClinicopathological significance of c-MET and HER2 altered expression in bladder cancer.
J Egypt Natl Canc Inst
December 2024
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Background: Tumor recurrence or metastasis after surgery is a significant factor influencing bladder cancer (BC) prognosis. Novel molecular biomarkers are necessary to determine each patient's specific outcome because current biomarkers have limited power for predicting prognosis. The proto-oncogene MET encodes c-MET, a tyrosine kinase receptor.
View Article and Find Full Text PDFMass Balance Recovery, Absorption, Metabolism, and Excretion of Elinzanetant in Healthy Human Volunteers and in vitro Biotransformation.
Eur J Drug Metab Pharmacokinet
December 2024
Preclinical Development-Drug Metabolism and Pharmacokinetics, Bayer AG, Berlin, Germany.
Background: Elinzanetant is a dual neurokinin-1,3 receptor antagonist in development for the treatment of menopausal vasomotor symptoms. The objectives of these studies were to characterize the mass balance and biotransformation of elinzanetant.
Methods: In the clinical evaluation, whole blood, plasma, urine, and feces were collected from healthy fasted male volunteers (n = 6) following a single dose of 120 mg [C]-elinzanetant oral suspension for analysis of total radioactivity and metabolite profiling.
Nursing students and role modeled behavior while caring for LGBTQ + people: a cross-sectional, descriptive study.
BMC Nurs
December 2024
Department of Nursing, University of New Hampshire, Hewitt Hall, 4 Library Way, Durham, NH, USA.
Background: While efforts to improve the educational preparedness of nurses to care for lesbian, gay, bisexual, transgender, and queer (LGBTQ +) people have increased, the influence of role-modeled behaviors by healthcare professionals working with nursing students and recent graduates is not well understood. The purpose of this study is to describe the role-modeled behaviors of healthcare professionals observed by nursing students and recent graduates caring for LGBTQ + patients in clinical settings.
Methods: A cross-sectional, online survey was conducted.
Frequency, redundancy, and context in bilingual acquisition.
J Child Lang
December 2024
Department of British Studies, University of Leipzig, Germany.
We report findings from a corpus-based investigation of three young children growing up in German-English bilingual environments ( = 3;0, Range = 2;3-3;11). Based on 2,146,179 single words and two-word combinations in naturalistic child speech (CS) and child-directed speech (CDS), we assessed the degree to which the frequency distribution of CDS predicted CS usage over time, and systematically identified CS that was over- or underrepresented in the corpus with respect to matched CDS baselines. Results showed that CDS explained 61% of the variance in CS single-word use and 19.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!