During the XVIII century, two Spanish scientific expeditions arrived here led, respectively, by the naturalist Martín Sessé and by the Italian mariner Alessandro Malaspina di Mulazzo, dependent from the Spanish Government. The members collected a rich scientific material, which was carried to Madrid in 1820. At the end of XVIII century, the Franciscan friar Juan Navarro depicted and described several Mexican medicinal plants in the fifth volume of his "American Garden". In the last years of the Colonial period, fundamental works of Humboldt and Bonpland, on the geographic distribution of the American plants, were published. At the end of the XIX century, the first researches on the Mexican medicinal botany were performed at the laboratory of the "Instituto Médico Nacional" under the leadership of doctor Fernando Altamirano, starting pharmacological studies in our country. During the first half of the XX century, trials of cardiovascular pharmacology were performed in the small laboratories of the cardiological unit at the General Hospital of Mexico, due to doctor Ignacio Chávez, initiative. Mexican botanical-pharmacological tradition remains alive and vigorous in the modern scientific institutes of the country.
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