Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845660 | PMC |
| http://dx.doi.org/10.1371/journal.ppat.1000816 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preserving a large number of essential yet highly unstable ribosomal DNA (rDNA) repeats is critical for the germline to perpetuate the genome through generations. Spontaneous rDNA loss must be countered by rDNA copy number (CN) expansion. Germline rDNA CN expansion is best understood in Drosophila melanogaster, which relies on unequal sister chromatid exchange (USCE) initiated by DNA breaks at rDNA.
View Article and Find Full Text PDFDeciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis.
Nat Commun
January 2025
Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.
Ex vivo expansion of hematopoietic stem cells (HSC) requires the maintenance of a stemness state while cells are proliferating. This can be achieved via exposure to UM171 which leads to the degradation of chromatin modifiers and prevents the loss of key epigenetic marks. However, the chromatin landscape varies across populations within the hematopoietic system and the effect of UM171 on self-renewal and differentiation potential of different hematopoietic progenitor cells is less characterized.
View Article and Find Full Text PDFThe Human Footprint and Climate Change Shape Current and Future Scenarios of Visceral Leishmaniasis Distribution in Doce River Basin in Brazil.
Am J Trop Med Hyg
December 2024
Graduate Program in Biological Sciences, Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil.
Article Synopsis
- The study investigates how environmental and climate factors affect the spread of visceral leishmaniasis (VL) in Brazil's Doce River basin, aiming to enhance future surveillance and control efforts.
- It utilizes ecological niche modeling, analyzing 855 VL cases from 2001-2018 to predict current and future disease distributions based on various climatic and environmental variables.
- Key findings indicate that human activities and climate change could increase VL suitable areas by 7% by 2041 and 12% by 2080, emphasizing the need for improved vector control initiatives in the region.
Research Progress of Triboelectric Nanogenerators for Ocean Wave Energy Harvesting.
Small
December 2024
Key Laboratory of Advanced Marine Materials, Key Laboratory of Marine Environmental Corrosion and Bio-Fouling, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.
The ocean wave energy is considered one of the most promising forms of marine blue energy due to its vast reserves and high energy density. However, traditional electromagnetic power generation technology suffers from drawbacks such as high maintenance costs, heavy structures, and low conversion efficiency, which restricts its application range. The triboelectric nanogenerator (TENG) uses Maxwell displacement current as its internal driving force, which can efficiently convert irregular, low-frequency, and dispersed mechanical energy into electrical energy.
View Article and Find Full Text PDFThe evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates.
Parasit Vectors
December 2024
Department of Tropical Diseases, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Background: The frequent communication between African and Southeast Asian (SEA) countries has led to the risk of imported malaria cases in the China-Myanmar border (CMB) region. Therefore, tracing the origins of new malaria infections is important in the maintenance of malaria-free zones in this border region. A new genotyping tool based on a robust mitochondrial (mt) /apicoplast (apico) barcode was developed to estimate genetic diversity and infer the evolutionary history of Plasmodium falciparum across the major distribution ranges.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!