Objectives: To compare the effects of a physiotherapist-supervised exercise programme in an exercise unit and self-supervised home exercise programme on quality of life in patients with Parkinson's disease.
Design: Assessor-blinded, quasi-randomized trial (alternate allocation).
Setting: An outpatient exercise unit; home settings.
Participants: Thirty patients with idiopathic Parkinson's disease, Hoehn & Yahr I-III, stable medication use.
Interventions: Patients were included in the physiotherapist-supervised or home group. The exercise programme was performed for 10 weeks, three times/week either under the supervision of a physiotherapist or at home without supervision.
Main Outcome Measures: Parkinson's Disease Quality of Life Questionnaire (PDQLQ), Nottingham Health Profile (NHP), Unified Parkinson's Disease Rating Scale (UPDRS), Beck Depression Inventory (BDI).
Results: Patients in the supervised physiotherapy group improved more than the home exercise group in Parkinson's Disease Quality of Life Questionnaire (total score, Parkinson's symptoms, emotional function), Nottingham Health Profile total, Unified Parkinson's Disease Rating Scale (all domains) and Beck Depression Inventory scores.
Conclusions: The exercise programme under physiotherapist supervision was found to be more effective at improving activities of daily living, motor, mental, emotional functions and general health quality in patients with Parkinson's disease compared with a self-supervised home programme.
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http://dx.doi.org/10.1177/0269215509358933 | DOI Listing |
Mol Neurodegener
January 2025
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise the possibility that pathogenic alpha-synuclein (⍺-syn) might develop in the GI tract and subsequently spread to susceptible brain regions. The cellular and mechanistic origins of ⍺-syn propagation in disease are under intense investigation.
View Article and Find Full Text PDFNat Med
January 2025
Department of Neurology & Neurological Sciences, Stanford Movement Disorders Center, Stanford University, Stanford, CA, USA.
Cerebral accumulation of alpha-synuclein (αSyn) aggregates is the hallmark event in a group of neurodegenerative diseases-collectively called synucleinopathies-which include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Currently, these are diagnosed by their clinical symptoms and definitively confirmed postmortem by the presence of αSyn deposits in the brain. Here, we summarize the drawbacks of the current clinical definition of synucleinopathies and outline the rationale for moving toward an earlier, biology-anchored definition of these disorders, with or without the presence of clinical symptoms.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
January 2025
Queensland Brain Institute, University of Queensland, Qld 4072, Australia; Queensland Centre for Mental Health Research, Wacol, Qld 4076, Australia. Electronic address:
Epidemiological studies often link circulatory levels of 25 hydroxy vitamin D with an overwhelming variety of disorders. Of such studies, an increasing number are now linking blood 25 hydroxy vitamin D levels with certain brain disorders. Prominent amongst such disorders are schizophrenia and Parkinson's disease.
View Article and Find Full Text PDFNeuroscience
January 2025
Faculty of Psychology, Potinficia Universidad Católica del Ecuador, Ecuador. Electronic address:
Understanding brain health is increasingly important, particularly in light of growing public health challenges related to neurological and psychiatric conditions. These include the rising prevalence of mental health disorders, such as depression and anxiety, as well as neurodegenerative diseases like Alzheimer's and Parkinson's. Lifestyle factors, including stress, poor diet, and insufficient physical activity, also significantly impact cognitive function.
View Article and Find Full Text PDFClin Neurophysiol
January 2025
Center of Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), São Bernardo do Campo, Brazil; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, São Paulo, Brazil. Electronic address:
Introduction: Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson's disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP).
Methods: The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG).
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