New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N,N-dimethyl-4-aminopyridine (DMAP) as a catalyst.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/znc-2010-1-205 | DOI Listing |
Publication Analysis
Top Keywords
antiviral activity
8
analogues acyclovir--synthesis
4
acyclovir--synthesis biological
4
biological activity
4
activity acyclovir
4
acyclovir esters
4
esters peptidomimetics
4
peptidomimetics synthesized
4
synthesized evaluated
4
evaluated vitro
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!