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THE USE OF ORAL BISPHOSPHONATES IN REFRACTORY SEVERE HYPERCALCEMIA AFTER DENOSUMAB CESSATION.
Acta Endocrinol (Buchar)
January 2025
Ankara University School of Medicine, Department of Pediatric Endocrinology.
Unlabelled: Denosumab,a monoclonal IgG2 antibody directed against RANK-L,is used as a neoadjuvant therapy for inoperable or metastatic giant cell tumor of bone. Many side effects like as hypocalcemia during treatment and rarely severe hypercalcemia especially in children after discontinuation of denosumab occurred. The unpredictable onset and recurrent episodes of severe hypercalcemia increase the duration of hospitalization and the risk of complications.
View Article and Find Full Text PDFPredictors, Trends, and Outcomes of Parathyroid Autotransplantation in Pediatric Total Thyroidectomy.
J Surg Res
December 2024
Division of Pediatric Surgery, Johns Hopkins All Children's Hospital, Saint Petersburg, Florida. Electronic address:
Article Synopsis
- The study looks at trends and outcomes of parathyroid autotransplantation (PTAT) in children undergoing total thyroidectomy, analyzing data from a surgical database.
- Of the 2,444 patients analyzed, a small percentage underwent PTAT, with the procedure being performed more frequently by adult subspecialists and in cases with more extensive lymph node removal.
- The overall use of PTAT declined over the study period, and no significant differences in early postoperative complications or hospital stays were noted between those who had PTAT and those who did not.
Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex).
Sci Rep
November 2024
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan.
Article Synopsis
- - Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic issue that negatively impacts the health and prognosis of CKD patients, making effective management crucial.
- - This study analyzed data from 30,977 CKD patients in the Japan Chronic Kidney Disease Database Extension to explore the link between proteinuria and CKD-MBD.
- - Results indicated that higher levels of proteinuria (up to 3+) are significantly associated with increased risks of hyperphosphatemia, hypocalcemia, and hypomagnesemia, regardless of kidney function measured by eGFR.
HLX07 alone or combined with serplulimab, cisplatin and 5-fluorouracil for advanced esophageal squamous cell carcinoma: A phase 2 study.
Cancer Commun (Lond)
December 2024
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Article Synopsis
- - The study evaluated the effectiveness of HLX07, an anti-EGFR antibody, when used alone or in combination with serplulimab and chemotherapy for treating advanced esophageal squamous cell carcinoma (ESCC).
- - In a trial with 50 patients, HLX07 alone showed a lower objective response rate (15.0%) and a shorter median progression-free survival (1.5 months), while the combination treatment had a higher response rate (60.0%) and longer median progression-free survival (7.8 months).
- - Adverse effects were observed, with 10% of patients on HLX07 experiencing severe side effects, and 46.7% of those receiving the combination treatment facing similar grade 3-
Assessment of neonatal glycaemic status and comorbidities in infants of diabetic mothers admitted to the neonatal care unit of Al-Ramadi Teaching Hospital for maternity and childhood, Iraq.
J Pak Med Assoc
October 2024
Department of Paediatrics, Mustansiriyah University, Baghdad, Iraq.
Objective: To assess neonatal and maternal characteristics, glycaemic status and comorbidities in the neonates of diabetic mothers.
Methods: The cross-sectional study was conducted from October 2021 to May 2022 at the Department of Physiology, College of Medicine, University of Mustansiriyah, Baghdad, Iraq, and comprised healthy women. Samples were raised by simple random technique.
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