Aims: Genetic contributions to nicotine dependence have been demonstrated repeatedly, but the relevance of individual polymorphisms for smoking cessation remains controversial.
Materials & Methods: We examined genotypes at two dopamine-related loci, DRD2/ANKK1 (rs1800497) and DBH (rs77905), in 577 heavy smokers participating in a prospective study of smoking cessation in general care in Germany.
Results: Smoking status after 1 year was significantly associated with DRD2/ANKK1, odds of abstinence being 4.4-fold (95% CI: 1.5-12.9) increased in TT- versus CC-homozygous subjects (p = 0.008). No effect was observed for the DBH genotype. The smoking cessation drug bupropion appeared to be particularly effective in CC-homozygotes (among CC subjects there was a 28% higher cessation probability among those taking buproprion; among T carrier subjects there was an increase only by 12%).
Conclusion: The large effects observed for DRD2/ANKK1 might be related to our study design, in which individual therapy was decided by the physician. Further studies are needed to clarify the genetic effects of DRD2/ANKK1 especially in 'real-life' settings outside clinical trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/pgs.10.1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A mixed-methods investigation of an ecological momentary assessment protocol for cigarette-smoking youth: Psychometric properties and participant experiences.
Drug Alcohol Depend Rep
March 2025
Radboud University, Postbus 9102, Nijmegen 6500 HC, the Netherlands.
Introduction: Ecological momentary assessment (EMA) is popular in smoking research to study time-varying processes and design just-in-time personalised cessation interventions. Yet, research examining the psychometric properties of EMA and user experiences with EMA protocols is lacking. We conducted a mixed-methods study to test the EMA component of a mobile intervention for middle to late-aged adolescents (16-20 years) who smoke cigarettes at least weekly.
View Article and Find Full Text PDFTargeted distribution of nicotine patches by mail to rural regions of Canada: Predictors of patch use.
Tob Prev Cessat
January 2025
Institute for Mental Health and Policy Research, Centre for Addiction and Mental Health, Toronto, Canada.
Introduction: Rural regions generally report higher smoking rates than urban centers, which increases the risk of tobacco related harms and consequences, and makes promoting smoking cessation in these areas a priority. Mass distribution of nicotine replacement therapy (NRT) by postal mail has been found to increase the odds of successful cessation attempts. Understanding factors that contribute to the use of NRT could help maximize this intervention's effectiveness.
View Article and Find Full Text PDFTobacco Treatment Disparities Among California Medicaid Members With and Without Chronic Disease Who Smoke.
AJPM Focus
February 2025
Center for Healthcare Policy Research, University of California, Davis, Sacramento, California.
Introduction: People who are covered by Medicaid have a higher smoking prevalence than the general population and are at an increased risk for tobacco-related disease, a major driver of Medicaid costs. California has the largest Medicaid program, called Medi-Cal, whose members also have higher tobacco-use rates and tobacco-related disease. Quitting is beneficial at any age, and health professional advice and assistance are a key indicator of smoking cessation.
View Article and Find Full Text PDFNeurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology.
Brain Res Bull
January 2025
Graduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Research Institute of Disaster Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Health and Disease Omics Center, Chiba University, Chiba, Japan. Electronic address:
Ischemic stroke (IS) is a pathological condition characterized by the cessation of blood flow due to factors such as thrombosis, inflicting severe damage to the cranial nervous system and resulting in numerous disabilities including memory impairments and hemiplegia. Despite the critical nature of this condition, therapeutic options remain limited, with a pressing challenge being the development of treatments aimed at restoring neurological function. In this study, we leveraged zebrafish, renowned for their exceptional regenerative capabilities, to analyze the pathology of IS and the subsequent recovery process.
View Article and Find Full Text PDFImpacto - A single-arm open-label pilot trial of a digital-based integrated smoking cessation program for Spanish-speaking Hispanic individuals who smoke: Development, feasibility, engagement, and clinical outcomes.
J Subst Use Addict Treat
January 2025
Rest of the World, Austin, TX, USA.
Introduction: Hispanic/Latinx (hereafter Hispanic) individuals who smoke have challenges in quitting and a disproportionate risk of smoking-related health problems when compared to the general population. The smoking inequalities among the Hispanic population are influenced by limited treatment access and chronic stress exposure (e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!