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Drug Development.
Alzheimers Dement
December 2024
Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom.
The recent positive phase 3 clinical trials of new treatments and their licensing and roll-out in the US and other countries represents a major turning point in Alzheimer's disease research. As has been the case with many other diseases, e.g.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) presents unique challenges in clinical trials involving small molecules. Multifaceted issues plague such trials, emphasizing susceptibility to fraud from clinical sites and "professional patients". The relative ease of simulating Alzheimer's diagnosis, coupled with inadequate oversight by Contract Research Organizations (CROs), creates fertile ground for deceptive practices.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
UsAgainstAlzheimer's, Washington, DC, USA.
Background: Previous What Matters Most (WMM) research identified and verified patient-important concepts among a diverse population of people living with Alzheimer's disease (PLWAD) and their care partners across all stages of Alzheimer's disease (AD). Additionally, a conceptual model of disease was developed using hypothesized domains and was further refined using qualitative data (Figure 1). This next phase of WMM research aims to quantify the importance of concepts, impacts, and outcomes and to determine priorities among PLWAD and care partners within a diverse sample including underrepresented ethnic and racial groups at each level of disease severity.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Johns Hopkins University School of Nursing, Baltimore, MD, USA.
Background: Community engagement is a key strategy to promoting health equity. While community advisory boards (CABs) are used as a popular tool for community engagement, the process of forming CABs and maintaining them is mostly missing in the literature. The purpose of this study is to showcase a set of processes our collaborative team went through to form and implement a CAB in the context of dementia literacy and linkage to dementia care research.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
CRIUGM, CIUSS Centre-Sud de l'Ile de Montréal, Montreal, QC, Canada.
Alzheimer's disease significantly impacts decision-making abilities, potentially increasing risk-taking behaviors and complicating the process of aging-in-place, particularly in cases of anosognosia (self-awareness impairment). To understand how this affects patient and caregiver perspectives, we conducted a qualitative study to identify arguments used by older patients with Alzheimer's disease and their family caregivers about aging-in-place. We included 18 dyads, each comprising an older adult living at home with mild dementia and their family caregiver.
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