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Approaches, barriers, and facilitators in statewide initiative to combat opioid overdose: A narrative review of Ohio's Experiences During the HEALing Communities Study.
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Department of Emergency Medicine, MetroHealth Medical Center, Cleveland, OH.
Objectives: Opioid-associated fatal and non-fatal overdose rates continue to rise. Prehospital overdose education and naloxone distribution (OEND) programs are attractive harm-reduction strategies, as patients who are not transported by EMS after receiving naloxone have limited access to other interventions. This narrative summary describes our experiences with prehospital implementation of evidence-based OEND practices across Ohio as part of the HEALing Communities Study (HCS).
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Department of Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraβe 15, 04318, Leipzig, Germany.
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious and costly and require a large number of vertebrate test animals. To reduce animal numbers and associated costs, the zebrafish embryo was proposed as an alternative model.
View Article and Find Full Text PDFEnhanced remediation of naphthalene from aqueous solutions using synthesized organoclay: characterization, mechanisms, and isotherms.
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Department of Civil and Environmental Engineering, Babol Noshirvani University of Technology, Babol, Iran.
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Soil and Water Research Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt.
Fusarium solani biomass plays a significant role in water pollution remediation due to its ability to sequester heavy metals, particularly cobalt (Co(II)) and cadmium (Cd(II)), which pose severe environmental and health risks. This study aimed to identify fungi from sewage-contaminated sites and evaluate their efficiency in absorbing and reducing Co(II) and Cd(II) ions. The biosorption potential of irradiated Fusarium solani biomass for removing Co(II) and Cd(II) ions from aqueous solutions was investigated.
View Article and Find Full Text PDFA weight of evidence review on the mode of action, adversity, and the human relevance of xylene's observed thyroid effects in rats.
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Product Stewardship, Science & Regulatory, Shell Global Solutions International B.V. The Hague, the Netherlands.
Xylene substances have wide industrial and consumer uses and are currently undergoing dossier and substance evaluation under Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) for further toxicological testing including consideration of an additional neurotoxicological testing cohort to an extended one-generation reproduction toxicity (EOGRT) study. New repeated dose study data on xylenes identify the thyroid as a potential target tissue, and therefore a weight of evidence review is provided to investigate whether or not xylene-mediated changes on the hypothalamus-pituitary-thyroid (HPT) axis are secondary to liver enzymatic induction and are of a magnitude that is relevant for neurological human health concerns. Multiple published studies confirm xylene-mediated increases in liver weight, hepatocellular hypertrophy, and liver enzymatic induction the oral or inhalation routes, including an increase in uridine 5'-diphospho-glucuronosyltransferase (UDP-GT) activity, the key step in thyroid hormone metabolism in rodents.
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