AI Article Synopsis
- Researchers evaluated serum (1 --> 3)-beta-D-glucan levels and clinical findings in 229 inpatients with connective tissue diseases (CTDs) from June to October 2004.
- The mean serum level was significantly higher in patients with fungal infections (129.7 pg/mL) compared to those without (10.5 pg/mL).
- The optimal cutoff for (1 --> 3)-beta-D-glucan to diagnose fungal infections in CTD patients was found to be 15 pg/mL, showing high sensitivity (92.3%) and specificity (81.3%).
Article Abstract
Serum (1 --> 3)-beta-D-glucan levels and clinical findings were evaluated in 229 inpatients with connective tissue diseases (CTDs) during the period between June and October 2004. The mean serum (1 --> 3)-beta-D-glucan level was 129.7 +/- 207.6 pg/mL in patients with a definitive diagnosis of fungal infections and 10.5 +/- 8.6 pg/mL in patients without fungal infections. Analysis of the diagnostic sensitivity/specificity for various (1 --> 3)-beta-D-glucan cutoff levels gave the best results for a cutoff level of 15 pg/mL, with a sensitivity of 92.3% and specificity of 81.3%. This level was therefore determined to be the optimal cutoff in patients with CTDs.
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| http://dx.doi.org/10.1007/s10165-010-0287-5 | DOI Listing |
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