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Induction of translation-suppressive G3BP1 stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA.
Hlife
January 2025
Tumor Virus RNA Biology Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Maryland, USA.
Plasmid DNA transfection is one of the fundamental tools of biomedical research. Here, we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell lines. Their activations were visible by detection of stress granules (SG) and cGAS-DNA condensates (cGC) in the transfected cells in a plasmid DNA dose-dependent manner.
View Article and Find Full Text PDFBiosafety and immunology: An interdisciplinary field for health priority.
Biosaf Health
October 2024
NHC Key Laboratory of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), Research Unit of Adaptive Evolution and Control of Emerging Viruses, Chinese Academy of Medical Sciences, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biosafety hazards can trigger a host immune response after infection, invasion, or contact with the host. Whether infection with a microorganism results in disease or biosafety concerns depends to a large extent on the immune status of the population. Therefore, it is essential to investigate the immunological characteristics of the host and the mechanisms of biological threats and agents to protect the host more effectively.
View Article and Find Full Text PDFHuman mpox co-infection with advanced HIV-1 and XDR-TB in a MSM patient previously vaccinated against smallpox: A case report.
Biosaf Health
June 2024
Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Mpox is a zoonotic infectious disease caused by the mpox virus (MPXV). Historically, the majority of mpox cases have been documented in Central Africa. However, since May 2022, there has been a notable rise in reported cases from regions beyond Africa.
View Article and Find Full Text PDFAdvances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with .
Biosaf Health
June 2024
Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
The high morbidity and mortality rate of individuals with human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS) coinfected with (MTB) is a tough challenge for current global tuberculosis prevention and control efforts. HIV/MTB coinfection is more complex than a single infection, and the interaction between the two diseases aggravates the deterioration caused by the disease, resulting in increased hospitalizations and deaths. Rapid screening and early diagnosis facilitate the timely initiation of anti-tuberculosis treatment in HIV/MTB coinfected individuals, thereby reducing transmission and the incidence of adverse prognoses.
View Article and Find Full Text PDFPediatricians' Discomfort With Pre-exposure Prophylaxis (PrEP) for HIV Prevention: The Need for Greater Education.
Cureus
February 2025
Pediatrics, University of Maryland School of Medicine, Baltimore, USA.
Objectives Despite being at a heightened risk of HIV, the use of pre-exposure prophylaxis (PrEP) among adolescents remains low, which may stem from access to this biomedical intervention and the comfort of providers caring for this priority population. Prior studies evaluating the comfort and knowledge of providers related to PrEP have focused on adult providers or been conducted prior to FDA approval of PrEP for adolescents. This study focuses on pediatric providers' knowledge and comfort regarding counseling and prescribing PrEP to adolescents.
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