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- Statins are a primary treatment for heterozygous familial hypercholesterolemia, but there's concern they may increase the risk of type 2 diabetes; however, some studies suggest these patients might actually have a lower prevalence of diabetes.
- A worldwide study analyzed data from nearly 25,000 adults with heterozygous familial hypercholesterolemia, looking at factors like age, BMI, and diabetes status while excluding certain groups to focus on the risk of type 2 diabetes.
- The results showed a 5.7% prevalence of type 2 diabetes in the overall population studied, with a lower rate of 4.1% among those with genetically confirmed heterozygous familial hypercholesterolemia
A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans.
EMBO J
November 2024
Andalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Pablo de Olavide, Junta de Andalucía, Carretera de Utrera, km 1, 41013, Sevilla, Spain.
Alterations in the nuclear envelope are linked to a variety of rare diseases termed laminopathies. A single amino acid substitution at position 12 (A12T) of the human nuclear envelope protein BAF (Barrier to Autointegration Factor) causes Néstor-Guillermo Progeria Syndrome (NGPS). This premature ageing condition leads to growth retardation and severe skeletal defects, but the underlying mechanisms are unknown.
View Article and Find Full Text PDFImpact of the COVID-19 pandemic on psychotropic prescribing: a systematic review.
BMJ Open
September 2024
Imperial Centre for Cardiovascular Disease Prevention (ICCP), Department of Primary Care and Public Health, Imperial College London, London, UK.
Objectives: The global prevalence of mental health disorders has risen significantly since the beginning of the COVID-19 pandemic. The pandemic has additionally caused disruption to mental health services, leading to a shift from in-person to remote service delivery. Given its long-term impact, it has become critical to evaluate whether changes in health delivery during the pandemic have had an effect on prescribing patterns for commonly prescribed psychotropic drugs.
View Article and Find Full Text PDFDetection of congenital heart disease by neonatologist performed cardiac ultrasound in preterm infants.
J Perinatol
October 2024
Neonatal Intensive Care Unit, King Edward's Hospital for Women, Perth, WA, Australia.
Objective: We aimed to assess the frequency of de novo congenital heart disease (CHD) detection via neonatologist-performed cardiac ultrasounds (NPCU) in premature infants born at <30 weeks of gestation.
Study Design: In this cross-sectional study (2004-2023) clinicians completing NPCU flagged de novo suspected CHD. All flagged NPCUs were cross-checked with cardiologists to confirm CHD diagnosis.
"Does My Kid Have an Ear Infection?" An Analysis of Pediatric Acute Otitis Media Videos on TikTok.
Laryngoscope
December 2024
Department of Surgery, Section of Otolaryngology - Head and Neck Surgery, University of Chicago, Chicago, Illinois, U.S.A.
Introduction: With the rise of social media, online platforms have become a common way to access healthcare information. This study examines the quality of pediatric acute otitis media (AOM) videos on TikTok, a popular short-form video social media platform.
Methods: A TikTok search was conducted between 8/18 and 8/19/2023 using pediatric AOM hashtags: #pediatric acute otitis media management, #kid ear infections remedy, #child ear infections treatment, and #kid ear infection.
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