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Cholesterol-terminated cationic lipidated oligomers (CLOs) as a new class of antifungals.
J Mater Chem B
January 2025
Drug Delivery, Disposition, and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville, VIC, 3052, Australia.
Infections caused by fungal pathogens are a global health problem, and have created an urgent need for new antimicrobial strategies. This report details the synthesis of lipidated 2-vinyl-4,4-dimethyl-5-oxazolone (VDM) oligomers an optimized Cu(0)-mediated reversible-deactivation radical polymerization (RDRP) approach. Cholesterol-Br was used as an initiator to synthesize a library of oligo-VDM (degree of polymerisation = 5, 10, 15, 20, and 25), with an α-terminal cholesterol group.
View Article and Find Full Text PDFPeer Audit and Feedback: A Documentation-Focused Quality Improvement Project.
Qual Manag Health Care
January 2025
Author Affiliations: Department of Medical Staff Quality, Corporate Quality, Atrium Health Waxhaw, North Carolina (Dr Glass); School of Nursing, College of Health and Human Services, UNC Charlotte Charlotte, North Carolina (Dr Powers); School of Nursing, College of Health & Human Services, UNC Charlotte Charlotte, North Carolina (Dr Magennis), and Nursing Excellence, Enterprise Nursing, Atrium Health Nursing Administration (Dr Shaw).
Background And Objectives: Nurses' documentation of communication, including notification of critical laboratory results (CLR), is important to ensure safe, high-quality care. Evidence supports peer audit with feedback as a quality improvement (QI) intervention to improve documentation. Nursing compliance with CLR documentation requirements was below goal for several years in an intensive care unit.
View Article and Find Full Text PDFMindful self-compassion for lung cancer (MSC-LC): Incorporating perspectives of lung cancer patients, clinicians, and researchers to create an adapted intervention to reduce lung cancer stigma.
Transl Behav Med
January 2025
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Stigma is a pervasive and distressing problem experienced frequently by lung cancer patients, and there is a lack of psychosocial interventions that target the reduction of lung cancer stigma. Mindful self-compassion (MSC) is an empirically supported intervention demonstrated to increase self-compassion and reduce feelings of shame and distress in non-cancer populations. However, there are several anticipated challenges for delivering MSC to lung cancer patients, and modifications may be needed to improve acceptability, appropriateness, and feasibility.
View Article and Find Full Text PDFDendritic alterations precede age-related dysphagia and nucleus ambiguus motor neuron death.
J Physiol
January 2025
Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Motor neurons (MNs) within the nucleus ambiguus innervate the skeletal muscles of the larynx, pharynx and oesophagus, which are essential for swallow. Disordered swallow (dysphagia) is a serious problem in elderly humans, increasing the risk of aspiration, a key contributor to mortality. Despite this importance, very little is known about the pathophysiology of ageing dysphagia and the relative importance of frank muscle weakness compared to timing/activation abnormalities.
View Article and Find Full Text PDFAttitudes and barriers to mobile mental health interventions among first-year college students: a mixed-methods study.
J Am Coll Health
January 2025
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Objective: This mixed-methods study examined attitudes, barriers, and preferences for mobile mental health interventions among first-year college students.
Participants: 351 students (64% women; 51% non-Hispanic White; 66% Heterosexual) from two campuses completed self-report assessments and 10 completed individual semi-structured interviews.
Methods: Paired t-tests compared attitudes for various mHealth applications and logistic regressions examined sociodemographic and clinical characteristics of mental health app users.
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