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Maternal NO exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.
Proc Natl Acad Sci U S A
October 2024
Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China.
Article Synopsis
- Epidemiological studies indicate that air pollution, specifically nitrogen dioxide (NO), is linked to fetal growth restriction (FGR), particularly when exposure occurs during the second trimester.
- A retrospective analysis of nearly 29,000 newborns showed a positive correlation between maternal NO exposure and the risk of having small-for-gestational-age babies, with a specific odds ratio calculated.
- Animal studies further confirmed that maternal NO inhalation affects embryonic development and the hematopoietic system, with findings suggesting that this exposure leads to placental hypoxia, thereby activating certain biological pathways that contribute to FGR.
Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis.
PLoS Med
September 2024
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Article Synopsis
- The study focuses on the effectiveness of 8-aminoquinolines (primaquine and tafenoquine) in curing Plasmodium vivax malaria by targeting hypnozoites, with a specific look at the role of methaemoglobin levels as a potential indicator for preventing malaria recurrence.
- The researchers conducted a systematic review of clinical studies from 2000 to 2022 and examined data from 1,747 patients treated with primaquine to analyze the relationship between methaemoglobin concentration and the time to malaria recurrence.
- Their findings suggest that higher methaemoglobin levels may correlate with a lower risk of P. vivax recurrence, indicating the potential use of methaemoglobin as
A Multi-Center Retrospective Database Evaluation of Pediatric Subjects Diagnosed With Methemoglobinemia.
Clin Med Insights Pediatr
September 2024
Pediatric Critical Care Medicine, Department of Pediatrics, Penn State Hershey Children's Hospital, Hershey, PA, USA.
Article Synopsis
- Methemoglobinemia is a rare condition in children, with a prevalence of only 0.0015% and a 30-day mortality rate of 6.1%.
- The study reviewed data from 98 children and found that those with higher methemoglobin levels (over 20%) received methylene blue treatment more frequently.
- There is a low rate of G6PD testing despite the risk it poses when administering methylene blue, indicating a need for improved clinician education regarding treatment and assessment of this disease.
Benzimidazolium Salt Modified Microporous Silica-Coupled Iron Oxide Nanoparticles: Material Engineered for Nitrate Removal.
ACS Appl Mater Interfaces
September 2024
Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab 140001, India.
Article Synopsis
- * The study involves creating a fluorescent chemosensor (KG3) that effectively detects nitrate ions in water, confirmed through various scientific methods with a very low detection limit of 0.032 μM.
- * KG3 is enhanced with iron oxide nanoparticles and silica to form a nanocomposite that efficiently removes 96% of nitrate ions from groundwater and can also detect nitrate ions using a mobile-based fluorescence sensing prototype.
Synergistic removal of bio-recalcitrant organic compounds and nitrate: Coupling photocatalysis and biodegradation to enhance the bioavailability of electron donors.
J Hazard Mater
November 2024
State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Ministry of Education Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, China. Electronic address:
Nitrate pollution poses significant threats to both aquatic ecosystems and human well-being, particularly due to eutrophication and increased risks of methemoglobinemia. Conventional treatment for nitrate-contaminated wastewater face challenges stemming from limited availability of carbon sources and the adverse impacts of toxins on denitrification processes. This study introduces an innovative Intimately Coupled Photocatalysis and Biodegradation (ICPB) system, which utilizes AgPO/BiTiO, denitrifying sludge, and polyurethane sponge within an anoxic environment.
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