In this paper, the development of a chiral phosphine-catalyzed formal [2 + 2] cycloaddition of aldehydes and ketoketenes that provides access to a variety of highly substituted beta-lactones (14 examples) is reported. The BINAPHANE catalytic system displays excellent enantioselectivity (seven examples with ee >or=90%) and high diastereoselectivity favoring formation of the trans-diastereomer (nine examples with dr >or=90:10).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol100075m | DOI Listing |
Publication Analysis
Top Keywords
phosphine-catalyzed asymmetric
4
asymmetric synthesis
4
synthesis beta-lactones
4
beta-lactones arylketoketenes
4
arylketoketenes aromatic
4
aromatic aldehydes
4
aldehydes paper
4
paper development
4
development chiral
4
chiral phosphine-catalyzed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!