This article examines the performance of four life-cycle portfolio allocation strategies through stochastic simulation based on observed U.S. asset returns during 1926-2008. Annual worker contributions to retirement savings accounts are based on the actual lifetime earnings histories maintained by the Social Security Administration for 12,871 workers born during 1915-1942. Each strategy's performance is evaluated primarily on the basis of the distributions of internal rates of return on investments calculated at the time of retirement. Comparisons are made with the performance of four other investment strategies that vary in terms of their exposure to stock and bond market risk. Life-cycle plans with larger portfolio weights assigned to equities have higher average returns, but those gains come at the cost of increased risk of infrequent bad outcomes.
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Nucleic Acids Res
January 2025
Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, United States.
The Rep68 protein from Adeno-Associated Virus (AAV) is a multifunctional SF3 helicase that performs most of the DNA transactions necessary for the viral life cycle. During AAV DNA replication, Rep68 assembles at the origin of replication, catalyzing the DNA melting and nicking reactions during the hairpin rolling replication process to complete the second-strand synthesis of the AAV genome. We report the cryo-electron microscopy structures of Rep68 bound to the adeno-associated virus integration site 1 in different nucleotide-bound states.
View Article and Find Full Text PDFFront Genet
January 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Objectives: This study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) treatment on the miRNA and mRNA profiles of stem cell-derived extracellular vesicles (EVs). Specifically, it sought to identify key miRNAs and their target mRNAs associated with enhanced therapeutic efficacy in LIPUS-treated stem cell-derived EVs.
Methods: Utilizing miRNA deep-sequencing data from the Gene Expression Omnibus database, differential gene analysis was performed.
Bioresour Technol
January 2025
School of Environment, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:
Carbon chain elongation offers a promising pathway for converting waste resources into caproate. However, challenges in yield and selectivity have limited its broader application. To address these limitations, anaerobically digested sludge-derived biochar (ADS-B) was incorporated into the carbon chain elongation process.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China; State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, and MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi University, Nanning 530004, China; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. Electronic address:
Regenerated cellulose is extensively utilized as a natural polymer due to its actually natural piezoelectric properties as well as renewable properties, but suffers from processing difficulties and low piezoelectric constants (d). Consequently, this work focuses on controlling the molecular weight of regenerated cellulose through pretreatment methods that promote the growth of in situ ZnO to enhance its d. Firstly, the acid-catalyzed pulp fibers (PF) and zinc nitrate hexahydrate were added in NaOH/urea solvent to effectively prepare RC/ZnO composite film via regeneration and in-situ growth.
View Article and Find Full Text PDFChemosphere
January 2025
Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Environmental Health Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
Per- and polyfluoroalkyl substances (PFASs) are widely used in consumer products and are easily encountered in daily life. PFASs that accumulate in the human body can negatively affect adolescent health. This study aimed to identify key exposure pathways that influence serum PFAS levels in Korean adolescents, using data from the Korean National Environmental Health Survey (2018-2020) cycle 4.
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