Craniospinal radiation is one of essential components in the treatment flow for a number of central nervous system malignancies. Meticulous attention to technique and dosimetry is required to produce optimum tumor control. In this paper, an optimized treatment regimen was proposed based on multiple techniques. The CT images for a 17-year-old male patient in need of craniospinal radiation were acquired for 3D conformal treatment planning. The split-beam technique, the extended penumbra fields matching technique, and the multiple leaf collimator segments and extended SSD technique were synthesized in the treatment regimen so as to work out an optimized treatment plan. The added few segments improved the dose homogeneity in spinal cord. The maximal point dose was decreased from 124% to 108% of the prescribed dose in it. Comparative study on the anthropomorphic phantom showed that the data collected by thermoluminescent detectors and the data obtained by calculation were basically coincident. These results suggest that the proposed technique be clinically acceptable.
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Adv Radiat Oncol
February 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Purpose: Treatment options for leptomeningeal metastasis (LM) are limited. A recent phase 2 study found that proton craniospinal irradiation (pCSI) was well-tolerated and improved survival. We report our experience with pCSI for solid-tumor LM.
View Article and Find Full Text PDFJ Neurosurg
January 2025
1Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima; and.
Objective: An MRI protocol for germinoma surveillance after complete remission has not been established. Moreover, the standard treatment for recurrent or refractory germinoma has not been determined. In this study, the authors explored the imaging characteristics of recurrent germinoma and discuss their institution's experience with multidisciplinary treatment of this malignancy.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
January 2025
National Center for Neurological Disorders, Shanghai 200052, China; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. Electronic address:
Background: To determine the optimal treatment modality for central nervous system (CNS) non-germinomatous germ cell tumors (NGGCTs).
Materials And Methods: A search of Medline, Embase, Web of Science and Cochrane Library was conducted up to September 30, 2024. All studies were considered, covering all CNS NGGCT patients with an informative treatment approach.
BMC Cancer
January 2025
National Center for Neurological Disorders, Shanghai, 200052, China.
Background: To determine the optimal treatment modality for intracranial germinoma (IG).
Materials And Methods: A search of Medline, Embase, Web of Science and Cochrane Library was conducted up to April, 2024. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated.
J Pers Med
November 2024
Department of Radiation Oncology, Miulli General Regional Hospital, Acquaviva delle Fonti, 70021 Bari, Italy.
. Adult medulloblastoma (AMB) patients should receive postoperative craniospinal irradiation (CSI) as a standard treatment. Volumetric intensity-modulated arc therapy (VMAT) is a promising method for CSI.
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