AI Article Synopsis
- Mycoplasma pneumoniae could lead to kidney issues in kids, but severe cases like glomerulonephritis are rare; this report presents an unusual case in a 3-year-old girl.
- The girl experienced nephrotic syndrome and poor kidney function, with her serum C3 complement levels initially low but normalizing after treatment.
- Treatment involved high-dose steroids, plasmapheresis, and additional medication, resulting in remission and improved kidney health, but controversy exists regarding the best treatment approach for such cases.
Article Abstract
Mycoplasma pneumoniae-associated nephritis has been reported in children with various pathological findings. It nevertheless remains an uncommon disease and, within this clinical context, endo-and extracapillary glomerulonephritis in a child has never been described. We report here a case of a 3-year-old girl diagnosed with severe crescentic glomerulonephritis associated with M. pneumoniae infection who presented with nephrotic syndrome and impaired renal function. The serum C3 complement level was initially low but returned to normal after 1 month. Two courses of three methylprednisolone pulses were administered in association with plasmapheresis and, secondarily, mycophenolate mophetil. This treatment regimen led to disease remission and a favorable renal outcome at the 6-month follow-up. However, the treatment guidelines in this situation remain debatable.
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| http://dx.doi.org/10.1007/s00467-010-1491-4 | DOI Listing |
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