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NIR-Reflective Black Photonic Films Designed for Effective LiDAR Recognition.
ACS Appl Mater Interfaces
January 2025
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Conventional dark-tone paints absorb both visible light and near-infrared (NIR) wavelengths, posing a challenge for light detection and ranging (LiDAR) recognition in autonomous driving. To overcome this issue, various chemical and structural coating materials have been explored to selectively reflect NIR. In this study, we newly propose colloidal photonic crystals with a stopband in the NIR range, fabricated through the spontaneous formation of crystalline arrays of silica particles dispersed in a photocurable resin, as a potential solution.
View Article and Find Full Text PDFTowards a Platform Chromatography Purification Process for Adeno-Associated Virus (AAV).
Biotechnol J
January 2025
School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.
Adeno-associated virus (AAV) is a versatile viral vector technology that can be engineered for specific functionality in vaccine and gene therapy applications. One of the major challenges in AAV production is the need for a GMP-ready platform-based approach to downstream processing, as this would lead to a standardized method for multiple products. Chromatography has huge potential in AAV purification, as it is a scalable method that would enable manufacturing to a high degree of purity, potency, and consistency.
View Article and Find Full Text PDFStructure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.
J Med Chem
January 2025
Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
The main protease M is a clinically validated target to treat infections by the coronavirus SARS-CoV-2. Among the first reported M inhibitors was the peptidomimetic α-ketoamide , whose cocrystal structure with M paved the way for multiple lead-finding studies. We established structure-activity relationships for the series by modifying residues at the P1', P3, and P4 sites.
View Article and Find Full Text PDFAdvances in Oxygen Evolution Reaction Electrocatalysts via Direct Oxygen-Oxygen Radical Coupling Pathway.
Adv Mater
January 2025
School of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, New South Wales, 2006, Australia.
Oxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO/N reduction, reversible fuel cells, and rechargeable metal-air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution mechanism (AEM), lattice oxygen oxidation mechanism (LOM), and oxide path mechanism (OPM). Unlike AEM and LOM, the OPM proceeds via direct oxygen-oxygen radical coupling that can bypass linear scaling relationships of reaction intermediates in AEM and avoid catalyst structural collapse in LOM, thereby enabling enhanced catalytic activity and stability.
View Article and Find Full Text PDFTargeting protein-ligand neosurfaces with a generalizable deep learning tool.
Nature
January 2025
Laboratory of Protein Design and Immunoengineering, Institute of Bioengineering, Ecole polytechnique fédérale de Lausanne, Lausanne, Switzerland.
Molecular recognition events between proteins drive biological processes in living systems. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field.
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