Antibacterial activity of aqueous and ethanol leaf extracts of Cadaba trifoliata was evaluated by cup plate method against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Acinetobacter, Enterobacter aerogenes, Erwinia and Escherichia coli. The ethanol extract of the leaves demonstrated a high degree of activity against all the tested bacterial strains except Erwinia and Acinetobacter, whereas the aqueous extract of the leaves showed moderate activity against E. coli, B. subtilis and Staph. aureus and Enterobacter aerogenes.
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http://dx.doi.org/10.4103/0250-474X.54271 | DOI Listing |
Macromol Biosci
January 2025
Universidade Estadual de Campinas (UNICAMP), School of Chemical Engineering (FEQ), Albert Einstein Avenue, 500, Campinas, São Paulo, 13083-852, Brazil.
Annually, thousands of individuals suffer from skin injuries resulting from trauma, surgeries, or diabetes. Inadequate wound treatment can delay healing and increase the risk of severe infections. In this context, a promising synthetic polymer with potent antimicrobial properties, Poly{2-[(methacryloyloxy)ethyl]trimethylammonium chloride} (PMETAC), is synthesized and crosslinked with N,N'-Methylenebis(acrylamide) (BIS) in the presence of Chitosan (CH), a natural, biocompatible polysaccharide that promotes cell regeneration and provides additional beneficial properties.
View Article and Find Full Text PDFPhytother Res
January 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
The rising prevalence of multidrug-resistant (MDR) Gram-positive bacteria threatens the effectiveness of current antibiotic therapies. However, the development of new antibiotics has stagnated in recent years, highlighted the critical need for the discovery of innovative antimicrobial agents. This study aims to evaluate the antibacterial activity of naphthoquinones derived from Arnebia euchroma (Royle) Johnst (ADNs) and elucidate their underlying mechanisms.
View Article and Find Full Text PDFFront Plant Sci
December 2024
Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, China.
Bacterial canker is a devastating disease in kiwifruit production, primarily caused by pv. . In this study, a strain of named JIN4, isolated from a kiwifruit branch, showed antagonistic activity.
View Article and Find Full Text PDFDrugs must accumulate at their target site to be effective, and inadequate uptake of drugs is a substantial barrier to the design of potent therapies. This is particularly true in the development of antibiotics, as bacteria possess numerous barriers to prevent chemical uptake. Designing compounds that circumvent bacterial barriers and accumulate to high levels in cells could dramatically improve the success rate of antibiotic candidates.
View Article and Find Full Text PDFUnlabelled: Despite recent advances, the regulation of anticancer and antimicrobial bioactive compound (AABC) production by leukocytes remains poorly understood. Here, we demonstrate that inactivation of the DNA- and RNA-based Teazeled receptors of the Universal Receptive System in human leukocytes generated so called "Leukocyte-Tells," which showed enhanced AABC production. Comprehensive analysis of the AABCs produced by Leukocyte-Tells based on LC/MS identified 707 unique or differentially produced peptide or non-peptide metabolites.
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