(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257265 | PMC |
| http://dx.doi.org/10.3390/molecules15031154 | DOI Listing |
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