This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1101/lm.960510 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis.
Ecotoxicol Environ Saf
January 2025
Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning, China; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, China. Electronic address:
Deltamethrin (DM), a broad-spectrum insecticide, is widely used in the world. It can exert direct action on the central nervous system to produce neurotoxicity. Exposure to DM can lead to iron metabolism disorder, oxidative stress and learning and memory dysfunction.
View Article and Find Full Text PDFA position coding model that accounts for the effects of event boundaries on temporal order memory.
Cogn Psychol
January 2025
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China; Chinese Institute for Brain Research, China. Electronic address:
Episodic memories, particularly temporal order memory, are influenced by event boundaries. Although numerous theoretical and computational models have been developed to explain this phenomenon, creating a model that can explain a wide range of behavioral data and is supported by neural evidence remains a significant challenge. This study presented a new model, grounded in ample evidence of position coding, to account for the impact of event boundaries on temporal order memory.
View Article and Find Full Text PDFHEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease.
Biomed Pharmacother
January 2025
Institut de Neurociències (INc), Universitat Autònoma Barcelona, Bellaterra 08193, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona 08035, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address:
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by amyloid-β and Tau protein depositions, with treatments focusing on single proteins have shown limited success due to the complexity of pathways involved. This study explored the potential of chronokines -proteins that modulate aging-related processes- as an alternative therapeutic approach. Specifically, we focused on a novel pleiotropic chimeric protein named HEBE, combining s-KL, sTREM2 and TIMP2, guided by bioinformatic analyses to ensure the preservation of each protein's conformation, crucial for their functions.
View Article and Find Full Text PDFDynamic classification and attention mechanism-based bidirectional long short-term memory network for daily runoff prediction in Aksu River basin, Northwest China.
J Environ Manage
January 2025
College of Hydrology and Water Resources, Hohai University, Nanjing 210098, China.
Inland river runoff variability is pivotal for maintaining regional ecological stability. Daily flow forecasting in arid regions is crucial in understanding water body ecological processes and promoting healthy river ecology. Precise daily runoff forecasting serves as a cornerstone for ecological evaluation, management, and decision-making.
View Article and Find Full Text PDFLuminance invariant encoding in mouse primary visual cortex.
Cell Rep
January 2025
Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address:
The visual system adapts to maintain sensitivity and selectivity over a large range of luminance intensities. One way that the retina maintains sensitivity across night and day is by switching between rod and cone photoreceptors, which alters the receptive fields and interneuronal correlations of retinal ganglion cells (RGCs). While these adaptations allow the retina to transmit visual information to the brain across environmental conditions, the code used for that transmission varies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!