AI Article Synopsis
- Glycolytic cancer cells depend on a process called trans-plasma membrane electron transport (tPMET) for survival, making it a potential target for new cancer drugs.
- The study tested various compounds to see how they affect the growth of human myelogenous leukemia cells, tPMET activity, and levels of NAD(P)H fluorescence.
- The findings highlight tPMET's crucial role in keeping leukemic cells alive, suggesting it could be a promising target for anti-leukemic therapies.
Article Abstract
The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.
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| http://dx.doi.org/10.1016/j.leukres.2010.02.032 | DOI Listing |
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