The objective of this study was a comparison of pentobarbital and T 61 in the euthanasia of cattle. 397 cattle of different ages and breeds which had to be euthanised in the Clinic for Ruminants were enrolled. Following clinical examination, euthanasia was performed by intravenous injection of either 40 mg pentobarbital per kg body weight (BW) (0.1 ml Eutha 77) or 0.1 ml T 61/kg BW. The intervals between the beginning of injection and the following events were noted: collapse of the animal, cessation of respiration, cessation of cardiac action, disappearance of the palpebral and corneal reflexes, and maximum dilatation of the pupils. These post-injection events occurred significantly earlier with Eutha 77. In addition, events like excitations and vocalisations were recorded. Excitations occurred twice as often with T 61 (in 34% of cases) than with Eutha 77 (17%), and strong excitations (grade 3 of 3) were also more frequent with T 61 (9.8%) than with Eutha 77 (3%). Vocalisations were less frequent (30%) with T 61 than with pentobarbital (39%), but this difference was not significant. Severe vocalisations occurred very rarely. With both drugs, intervals between the beginning of injection until cessation of reflexes were longer in older animals. Following injection of Eutha 77, cessation of the corneal reflex and maximal dilatation of the pupils occurred earlier in cattle with severe disturbance of the general condition than in cattle with lesser disturbance; in the T 61-group this difference was only significant for the interval until cessation of the corneal reflex. In anaesthetized patients euthanized with T 61 cessation of cardiac action and respiration occurred earlier than in patients that were not under general anaesthesia when euthanized; in the Eutha 77 group, the difference was significant only for the interval until cessation of cardiac action.
Download full-text PDF |
Source |
---|
J Clin Psychiatry
January 2025
Psychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.
Individuals with severe mental illness (SMI) have a shorter life expectancy compared to the general population, largely due to cardiovascular disease (CVD). In this report from the Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients (FITNESS), we examined baseline CVD risk factors and their treatment in patients with SMI and second generation antipsychotic (SGA) use. FITNESS enrolled 204 participants with SMI and SGA use, but without documented history of CVD or diabetes mellitus, from several clinics in the Boston, Massachusetts, area between April 29, 2015, and September 26, 2019.
View Article and Find Full Text PDFResusc Plus
December 2024
Division of Cardiology, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, United States.
Background: Extracorporeal life support (ECLS) provides organ perfusion in refractory cardiac arrest but during the initiation of ECLS mean arterial pressure (MAP) and carotid flow may be suboptimal due to hypotension and/or insufficient flow. We hypothesized that cardiopulmonary resuscitation (CPR) in addition to ECLS may increase carotid flow and MAP compared to ECLS alone.
Methods: Observational pilot study comparing hemodynamic parameters before and after CPR cessation in pigs supported by ECLS for experimental refractory cardiac arrest.
Acta Paediatr
January 2025
Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Aim: We evaluated whether sample entropy of heart rate time series could serve as a biomarker for guiding caffeine cessation in preterm infants treated for apnoea of prematurity (AOP). We also assessed associations of sample entropy with weeks of gestation, clinical morbidity, AOP frequency and caffeine reinitiation.
Methods: We conducted a prospective single-centre study at the University Children's Hospital Basel, Switzerland, from July 2019 to June 2020.
JTCVS Open
December 2024
Department of Cardiac Surgery, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.
Objectives: This study aims to investigate the association between interatrial conduction block and postoperative atrial fibrillation, which can precipitate acute cardiopulmonary instability and is associated with subsequent heart failure, stroke, and mortality following cardiac surgery.
Methods: Perioperative 12-channel electrocardiograms from 3405 patients undergoing myocardial revascularization, valve surgery, aortic surgery, or combinations thereof, were considered. Clinical and electrographic parameters were compared between patients with and without atrial fibrillation, and significant variables were analyzed using univariate and multivariate logistic regression.
J Sci Med Sport
December 2024
Korey Stringer Institute, Department of Kinesiology, University of Connecticut, United States of America.
Prehospital management of exertional heat stroke (EHS) consists of monitoring rectal temperature (T) while aggressively cooling via cold water immersion. Recent recommendations suggest using central nervous system (CNS) dysfunction to determine cessation of cooling when T is not available. We examined cognitive responses of two runners with EHS after a road race.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!