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Trial of alginates in throat symptoms: protocol for a pragmatic, multicentre, placebo controlled, double blind, parallel, randomised controlled trial of liquid alginate (Gaviscon Advance) for the treatment of persistent throat symptoms.
BMJ Open
January 2025
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK
Introduction: Persistent throat symptoms (PTS) are indicators for over 60 000 new patient referrals to NHS secondary care annually. PTS have been attributed to manifestation of gastro-oesophageal reflux disease (GORD) with the hypothesis that gastric refluxate damages and irritates the mucosa of the upper aerodigestive tract. Symptoms of PTS and GORD are commonly treated with proton pump inhibitors (PPIs) or alginates are often, incorrectly, advocated.
View Article and Find Full Text PDFSepiolite-Chitosan-Acetic Acid Biocomposite Attenuates the Development of Obesity and Nonalcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet.
Nutrients
November 2024
Laboratory of Integrative Physiology, The Department of Nutrition and Natural Products, MIGAL-Galilee Research Institute, P.O. Box 831, Kiryat Shmona 11016, Israel.
Background; obesity and nonalcoholic fatty liver disease (NAFLD) reduce life expectancy; nonoperative interventions show poor results. Individually, chitosan (1% /), acetic acid (AA 0.3-6.
View Article and Find Full Text PDFLanthanum-modified sepiolite for real application of phosphate removal from rural sewage.
Environ Sci Pollut Res Int
December 2024
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Being able to cause eutrophication, a severe ecological problem that leads to the demise of aquatic animals, excessive phosphate in water bodies, has been a threat to the environment. Aiming to remove phosphate from wastewater in rural areas, adsorption is a promising method. In this study, a novel phosphate adsorbent, SEP-La, was synthesized by doping lanthanum into sepiolite.
View Article and Find Full Text PDFCopper functionalized, pro-angiogenic, and skin regenerative scaffolds based on novel chitosan/APDEMS modified sepiolite-based formulation.
Int J Biol Macromol
December 2024
Institute of Zoology, University of the Punjab, Lahore, Pakistan.
Article Synopsis
- Biomaterials-based scaffolds using chitosan and modified sepiolite with copper were developed for enhanced wound healing and angiogenesis.
- The optimal scaffold, CS/MS/Cu0.1, showed significant improvements in mechanical properties and swelling ability, leading to effective tissue regeneration.
- In vivo studies indicated that these scaffolds promoted faster wound healing and collagen deposition without causing toxicity, highlighting their potential for clinical applications in regenerative medicine.
Effective co-immobilization of arsenic and cadmium in contaminated soil by sepiolite-modified nano-zero-valent iron and its impact on the soil bacterial community.
Sci Rep
October 2024
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agriculture Sciences, Beijing, 100081, China.
Sepiolite-modified nano-zero-valent iron (S-nZVI) is used as an amendment and incubated to remediate As-Cd-contaminated soil under three different soil‒water management conditions [moderately wet (MW), continuously flooded (CF) and alternately wet and dry (AWD)]. The results showed that soil pH is in the order of CF > AWD > MW. The soil pH increased approximately 0.
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