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Pertussis Vaccination for Adults: An Updated Guide for Clinicians.
Vaccines (Basel)
January 2025
Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore 119074, Singapore.
Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the Gram-negative bacterium . Although traditionally associated with children, pertussis is increasingly prevalent among adults, particularly those with comorbidities or weakened immune systems, where it can lead to severe complications. Diagnosing pertussis in adults can be challenging due to its nonspecific symptoms, underreporting, and the limited sensitivity of available diagnostic tests.
View Article and Find Full Text PDFBurden of pertussis in infants in the Eastern Mediterranean Region and the impact of maternal vaccination: a systematic review.
BMC Public Health
January 2025
Polio and Immunization, Public Health Programs, Global Health Development| Eastern Mediterranean Public Health Network, Beirut, Lebanon.
Background: Despite vaccine availability, Pertussis remains a global public health challenge, especially among infants. The Eastern Mediterranean Region (EMR) presents a diverse epidemiological landscape with varying vaccination coverages and healthcare infrastructures. This systematic review aimed to assess the burden of pertussis in infants < 1 year of age in the EMR and evaluate the use and impact of pertussis vaccination during pregnancy.
View Article and Find Full Text PDFA new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease.
Ital J Pediatr
January 2025
Unit of Microbiology and Diagnostic Immunology, Bambino Gesù Children's Hospital, IRCSS, Rome, 00165, Italy.
Background: In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.
View Article and Find Full Text PDFSevere pertussis infections in pediatric intensive care units: a multicenter study.
Eur J Pediatr
January 2025
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Unlabelled: This study aims to evaluate the clinical course of critical pertussis illness to the pediatric intensive care unit in Istanbul. The study was conducted as a multicenter, retrospective study between January 1, 2023, and December 31, 2023. Cases with positive polymerase chain reaction testing for Bordetella pertussis of nasopharyngeal swab samples within the first 24 h of pediatric intensive care unit admission were recorded.
View Article and Find Full Text PDF[Issues and recommendations on antibacterial treatment and post-exposure chemoprophylaxis for pertussis].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Infectious Disease,Children's Hospital of Fudan University, National Children's Medical Center (Shanghai), Shanghai 200032, China.
Pertussis is an important public health and clinical issue in China currently. Macrolide resistance in is a serious challenge to prevent and manage pertussis in China. Early, timely and effective antimicrobial therapy plays an important role in alleviating disease, reducing complications and severe diseases, eliminating carriers and reducing secondary transmission, and implementing post-exposure chemoprophylaxis in special scenarios is also necessary to protect individuals at high risk of severe diseases.
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