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Artisse intrasaccular device for intracranial aneurysm treatment: a technical video case.
J Neurointerv Surg
January 2025
Lyerly Neurosurgery, Baptist Medical Center Jacksonville, Jacksonville, Florida, USA
The Artisse intrasaccular device (Medtronic) offers a novel treatment option for unruptured and ruptured wide-neck bifurcating intracranial aneurysms.1 2The Artisse device features enhancements including a distal tip for dome protection, platinum band markers for improved visibility, and a bilayer high-density platinum core nitinol mesh basket for enhanced flexibility and visibility when compared with previous devices.2-7 Data from case series demonstrate the procedural safety and efficacy of the Artisse device.
View Article and Find Full Text PDF'Home inspections' for life sciences companies going public before clinical proof-of-concept.
Drug Discov Today
December 2024
PAASP, Am Aukopf 14/1, Heidelberg 69118, Germany.
For the period from 2010 to 2021, we have observed a phenomenon of life sciences companies conducting Initial Public Offerings (IPOs) without any assets that have demonstrated clinical proof-of-concept (POC). Ideally, this area of investment is targeted by investors with the knowledge and resources to assess the probability of success of such early-stage programs based upon adequately planned and performed due diligence. Our analysis of this trend calls for the establishment of a standardized 'home inspection' procedure that would better inform public equity investors buying into such pre-POC companies about inherent uncertainties that few might be aware of and that even fewer would be equipped to assess.
View Article and Find Full Text PDFSuccess Factors of Growth-Stage Digital Health Companies: Systematic Literature Review.
J Med Internet Res
December 2024
Centre for Digital Health Interventions, School of Medicine, University of St. Gallen, St. Gallen, Switzerland.
Article Synopsis
- Over the last decade, digital health technologies (DHTs) have rapidly developed, particularly due to electronic health records and the COVID-19 pandemic, but many companies like Pear Therapeutics and Proteus Digital Health have faced challenges scaling and some even went bankrupt.
- The study aims to identify success factors for growth-stage DHT companies by examining general and specific factors, as well as variations among different companies within the sector.
- Through a systematic review of 2972 studies, the research identified 52 success factors categorized into internal factors (like product and team composition) and external factors (including customers and regulatory influences).
International Consensus Statement on Platelet Function and Genetic Testing in Percutaneous Coronary Intervention: 2024 Update.
JACC Cardiovasc Interv
November 2024
Medizinische Klinik und Poliklinik I, University Hospital Munich, Ludwig-Maximilians University, Munich, Germany; Privatklinik Lauterbacher Mühle am Ostsee, Seeshaupt, Germany.
Current evidence indicates that dual antiplatelet therapy with aspirin plus a P2Y inhibitor is essential for the prevention of thrombotic events after percutaneous coronary interventions. However, dual antiplatelet therapy is associated with increased bleeding which may outweigh the benefits. This has set the foundations for customizing antiplatelet treatments to the individual patient.
View Article and Find Full Text PDFSubstitute Yeast Extract While Maintaining Performance: Showcase Amorpha-4,11-Diene Production.
Microb Biotechnol
November 2024
Institute of Biochemical Engineering, University of Stuttgart, Stuttgart, Germany.
Yeast extract (YE) is a complex nutritional source associated with high performance on microbial production processes. However, its inherent compositional variability challenges its scalability. While prior efforts have focused on growth-associated products, the dynamics of growth-uncoupled production, which leads to higher production rates and conversion yields, still need to be explored.
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