AI Article Synopsis
- Frequencies of HLA class 1-specific cytotoxic T lymphocyte precursors (CTLp) were measured across various responder/stimulator combinations, revealing a wide range of CTLp frequencies, particularly for HLA-A and HLA-B antigens.
- Some A locus antigens were shown to be less immunogenic, and C locus differences had minimal impact on CTLp frequencies, suggesting that the HLA relationship of responders and stimulators is not critically important.
- The study proposes that CTLp frequency analysis could become an important factor in clinical transplantation to help select suitable donor/recipient pairs.
Article Abstract
Frequencies of HLA class 1-specific cytotoxic T lymphocyte precursors (CTLp) from 33 responders were determined in 115 responder/stimulator combinations. In each combination there was a single HLA-A or HLA-B antigen mismatch. A wide range of CTLp frequency (CTLpf) values was found for most A and B locus antigens. Some A locus antigens appeared less immunogenic than other A locus antigens. The effect of additional C locus differences was negligible. The relationship between responder and stimulator HLA antigens is of minor importance because HLA-specific CTLpf against crossreactive (CREG) and subtype antigens were not significantly lower than CTLpf against non-CREG antigens. The CTLpf did not correlate with Bw4 or Bw6 mismatches. The existence of a broad range of values for HLA class I-specific CTLpf is of general interest. We have arbitrarily subdivided the CTLpf values into high, medium, low, and very low. In about 20% of the combinations the HLA-specific CTLpf were low or not even detectable in our assay. In contrast, HLA-specific CTLpf in combinations with multiple HLA antigen differences were regularly high. Our results confirm the high values of allospecific CTLpf in general but simultaneously point to unexpected variations. Frequency analysis of HLA-specific CTLp may be considered a new parameter in clinical transplantation for the selection of appropriate donor/recipient pairs.
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| http://dx.doi.org/10.1097/00007890-199105000-00032 | DOI Listing |
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