The second quarter of 2009 saw steady advances in bone marrow biopsy (BMB) pathology. The following publications are a personal selection of the highlights. Quality issues in diagnostic immunohistochemistry for BMB have largely been ignored in external quality assurance programmes, and this issue is highlighted. In other areas, publications reflecting advances in flow cytometry and aspirate morphology are discussed where translation to the BMB is possible. Classifications undergo constant change, and several publications address the redefinition of the cut off points between malignancy, benign, and normal. Lastly, current scientific research is presented where it is relevant to the understanding of BMB pathobiology.
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http://dx.doi.org/10.1007/s12308-009-0045-9 | DOI Listing |
BMC Musculoskelet Disord
January 2025
Division of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Background: Despite advancements in prosthetic designs and surgical techniques, patellar dislocation remains a rare but significant complication following total knee arthroplasty, with an incidence ranging between 0.15% and 0.5%.
View Article and Find Full Text PDFJ Knee Surg
January 2025
Lenox Hill Hospital Department of Orthopedic Surgery, Northwell Health, New York, United States.
Patellar instability following total knee arthroplasty (TKA) is a rare, yet serious complication, potentially requiring revision surgery or resulting in chronic dysfunction. When encountered, it is paramount to understand the etiologies, diagnostic approaches, treatment options, and outcomes of the selected treatment. The most common cause of patella instability is improper positioning of components, leading to lateral maltracking of the patella.
View Article and Find Full Text PDFCell Stem Cell
January 2025
Division of Hematopoietic Innovative Therapies, CIEMAT, Madrid, Spain; Instituto Nacional de Investigación Biomédica en Enfermedades Raras (CIBERER), Madrid, Spain; Advanced Therapies Unit, IIS-Fundación Jimenez Diaz (IIS-FJD, UAM), 28040 Madrid, Spain. Electronic address:
Diamond-Blackfan anemia syndrome is a ribosomopathy classified among the bone marrow failure syndromes. This disease exhibits significant heterogeneity, with up to 24 genetic variants identified to date. Voit et al.
View Article and Find Full Text PDFPhytomedicine
December 2024
Department of Hematology, Liuzhou People's Hospital affiliated to Guangxi Medical University, Xining, Qinghai, China; Department of Hematology, The Qinghai Provincial People's Hospital, Xining, Qinghai, China. Electronic address:
Osteosarcoma is an aggressive malignant bone tumor with an obscure etiology, as well as high prevalence and poor prognosis in children and adolescents. We aimed to investigate the pathogenesis of osteosarcoma through a comprehensive analysis of the tumor immune microenvironment (TIME) using multiple single-cell RNA sequencing datasets. SLC25A5, a gene implicated in cellular aging, significantly influenced osteosarcoma development by altering the TIME and promoting CD8+ T cell exhaustion, which contributed to reduced chemosensitivity.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea. Electronic address:
Tissue engineering offers an alternative approach to developing biological substitutes that restore, maintain, or enhance tissue functionality by integrating principles from medicine, biology, and engineering. In this context, biopolymer-based electrospun nanofibers have emerged as attractive platforms due to their superior physicochemical properties, including excellent biocompatibility, non-toxicity, and desirable biodegradability, compared to synthetic polymers. Considerable efforts have been dedicated to developing suitable substitutes for various biomedical applications, with electrospinning receiving considerable attention as a versatile technique for fabricating nanofibrous platforms.
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