Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851886 | PMC |
| http://dx.doi.org/10.1073/pnas.1001277107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
link to poor prognosis and immune infiltration of head and neck squamous cell carcinomas.
Transl Cancer Res
November 2024
Department of Stomatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Background: Head and neck squamous cell carcinomas (HNSCs) are a diverse collection of tumors that originate in the oral cavity, pharynx, and larynx and pose a severe threat to human health, contributing to a fast-rising burden of cancer morbidity and mortality. The search for prognostic biomarkers of HNSC has been a hot topic. Spindle and kinetochore-associated () complex, including three members , which stabilize the spindle microtubules at the kinetosite during mitosis metaphase, has been demonstrated to be associated with poor prognosis of different cancers.
View Article and Find Full Text PDFSKA1/2/3 is a prognostic and predictive biomarker in esophageal adenocarcinoma and squamous cell carcinoma.
BMC Cancer
November 2024
Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong Province, 272029, P. R. China.
Background: Esophageal carcinoma (ESCA) ranks among the most prevalent malignant tumors globally. Despite significant advancements in treatment options and improved patient outcomes, the 5-year survival rate remains unsatisfactory. The spindle and kinetochore associated complex subunit 1/2/3 (SKA1/2/3) attached to the kinetochore (KT) in the metaphase of mitosis are implicated in the occurrence and development of various tumors.
View Article and Find Full Text PDFKNTC1 functions as a potential biomarker and oncogene regulating proliferation, migration and apoptosis in gastric cancer.
Int Immunopharmacol
December 2024
Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province 450001, PR China; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, Henan Province 450001, PR China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan Province 450052, PR China. Electronic address:
Background: As one of the most prevalent cancers, gastric cancer (GC) exhibits a remarkably high morbidity and mortality rate. To date, effective diagnostic and prognostic markers and therapeutic targets for GC are still lacking. Kinetochore associated 1 (KNTC1) is one of the proteins involved in chromosome segregation.
View Article and Find Full Text PDFPLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer.
Radiat Oncol
February 2024
Department of Anatomy and Cell Biology, Western University, N6A 3K7, London, ON, Canada.
Radioresistance is one of the barriers to developing more effective therapies against the most aggressive, triple-negative, breast cancer (TNBC) subtype. In our previous studies, we showed that inhibition of Polo-like Kinase 4 (PLK4) by a novel drug, CFI-400945 significantly enhances the anticancer effects of radiotherapy (RT) compared to single treatment alone. Here we further investigate the role of PLK4 in enhancing radiation effects in TNBC and explore mechanisms of PLK4 inhibition and radiation combinatorial antiproliferative effects.
View Article and Find Full Text PDFThe Clinical, Genomic, and Transcriptomic Landscape of BRAF Mutant Cancers.
Cancers (Basel)
January 2024
Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H4A 3T2, Canada.
Background: BRAF mutations are classified into four molecularly distinct groups, and Class 1 (V600) mutant tumors are treated with targeted therapies. Effective treatment has not been established for Class 2/3 or BRAF Fusions. We investigated whether BRAF mutation class differed according to clinical, genomic, and transcriptomic variables in cancer patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!