AI Article Synopsis
- - This study focuses on modifying silicon nanowires (SiNWs) with bisphosphonates, particularly the antiosteoporotic drug alendronate, to enhance their medicinal properties for orthopedic use.
- - Researchers assessed how the attachment of bisphosphonates affects acellular calcification in conditions mimicking plasma to determine their efficacy.
- - Proliferation tests on mesenchymal stem cells revealed that the type of bisphosphonate used significantly influences the cytotoxic effects of the modified nanowires.
Article Abstract
Medicinal surface modification of silicon nanowires (SiNWs) with selected bisphosphonates, such as the known antiosteoporotic drug alendronate, is described. In terms of specific assays relevant to orthopedic applications, the impact of selected bisphosphonate attachment on acellular calcification in simulated plasma is reported. To further investigate biocompatibility, proliferation assays of these modified nanowires were carried out using an orthopedically relevant cell line: mesenchymal stem cells derived from mouse stroma. It is found that the identity of the bisphosphonate ligand strongly and sensitively impacts its resultant cytotoxicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841355 | PMC |
| http://dx.doi.org/10.1021/am800219r | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!