AI Article Synopsis
- - Clinical data indicates a strong link between tobacco and alcohol use and the risk of developing oral squamous cell carcinoma (SCC), suggesting the oral mucosa plays a role in metabolizing carcinogens.
- - Glutathione S-transferases (GSTs) are important enzymes that help detoxify carcinogens, and individuals lacking certain GST isoforms are at a higher cancer risk.
- - This pilot study found that GST activity is higher in SCC tissues compared to normal oral tissue, indicating that GSTs are upregulated in some precancerous and cancerous oral lesions.
Article Abstract
Clinical data show a strong correlation between tobacco and alcohol use and the development of oral squamous cell carcinoma (SCC). While this association implies that the oral mucosa actively metabolizes carcinogens, there is little information which depicts the carcinogen metabolizing enzymes within the oral cavity. Glutathione S-transferases (GSTs) primary function is to detoxify carcinogens by increasing their water solubility, GSTs represent key carcinogen metabolizing enzymes. Notably, individuals with a null phenotype for certain GST isoforms are at an increased risk to develop cancer. This study investigated the function and distribution of GSTs in human oral tissues. Our results from this pilot study showed a trend towards higher GST activities in SCC tissues relative to normal mucosa. Also, relative to normal tissues, the SCC and epithelial dysplasia samples showed a more intense and uniform GST intracellular distribution. GST activities are increased in many high grade cancers. Similarly, our data suggest that GST upregulation occurs in at least a subset of precancerous and malignant oral lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841403 | PMC |
| http://dx.doi.org/10.4137/cmo.s491 | DOI Listing |
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