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Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database.
Discov Oncol
January 2025
Department of Neurosurgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, 415003, Hunan, China.
Purpose: Glioma is the most prevalent tumor of the central nervous system. The poor clinical outcomes and limited therapeutic efficacy underscore the urgent need for early diagnosis and an optimized prognostic approach for glioma. Therefore, the aim of this study was to identify sensitive biomarkers for glioma.
View Article and Find Full Text PDFT-branch by partial deployment technique in the endovascular repair of complex aortic and thoracoabdominal aneurysms with narrow or severe angulated para-visceral aorta.
J Vasc Surg
January 2025
Vascular Surgery, University of Bologna, DIMEC, Bologna, Italy; Vascular Surgery Unit, IRCCS Sant'Orsola, Bologna, Italy.
Introduction/aim: The partial deployment technique (PDT) is an unconventional option of T-branch deployment to allow target arteries (TAs) cannulation/stenting from the upper arm access, in case of narrow (NPA: <25mm) or severely angulated (APA: >60°) aorta. Aim of this study was to report outcomes of the endovascular repair of complex aortic (c-AAAs) and thoracoabdominal (TAAAs) aneurysms by T-branch and PDT.
Methods: All consecutive patients underwent urgent endovascular repair of c-AAAs and TAAAs by T-branch (Cook-Medical, Bloomington, IN, US) and PDT from 2021 to 2023 were analyzed.
A signal amplifying MOF-based probe:on-site and ultrasensitive dual-channel portable detection of Hg in groundwater through a fluorimetrically and RGB-based sensing assay.
Talanta
January 2025
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China. Electronic address:
Mercury (II) ions (Hg) are a significant source of heavy metal contamination in groundwater, posing a serious threat to human health and the environment. Therefore, there is an urgent need for the development of a new detection technique with high sensitivity for monitoring Hg in contaminated groundwater. Here, we developed a signal amplifying MOF-based probe (NXS@ZIF-8) for on-site and ultrasensitive dual-channel portable detection of Hg in groundwater.
View Article and Find Full Text PDFExploring the challenges which influence general dental practitioners' participation as educational supervisors in dental foundation training in the South West of England.
Br Dent J
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Professor, Primary Care Dentistry, Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, Devon, UK.
Introduction The challenges of recruitment and retention of dentists within the NHS are a major contributory factor in delivering dental access. Availability and geographical location of dental foundation training (DFT) placements is considered to be an important element in recruiting new dental graduates to poorly served areas. A recent decline in the number of dentists applying to act as educational supervisors (ESs) for DFT has been observed, which could have a direct impact on the future sustainability of NHS services.
View Article and Find Full Text PDFBreaking research silos to achieve equitable precision medicine in rheumatology.
Nat Rev Rheumatol
January 2025
Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, USA.
Health disparities in rheumatic disease are well established and urgently need addressing. Obstacles to precision medicine equity span both the clinical and the research domains, with a focus placed on structural barriers limiting equitable health care access and inclusivity in research. Less articulated factors include the use of inaccurate population descriptors and the existence of research silos in rheumatology research, which creates a knowledge gap that precludes addressing the health disparities and fulfilling the goals of precision medicine to understand the 'full patient'.
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