Natriuretic peptides (NPs) exert their actions through three membrane-bound receptors, which are known as NP receptors (NPRs: NPR-A, NPR-B and NPR-C). In this work we examined the expression of three NPRs in rat retinal ganglion cells (GCs), retrogradely labeled and intracellularly dye-injected, by double immunofluorescence labeling. In vertical sections, almost all GCs, retrogradely labeled by cholera toxin B, were stained by antibodies against the three NPRs. The labeling for three NPRs was observed mainly on the membranes of the somata of GCs, whereas the staining for NPR-A was also seen in the cytoplasm. Moreover, with tangential sections, almost all cells located in the ganglion cell layer were NPR-A, B, C immunoreactive. By combining with intracellular injection of Neurobiotin into GCs in whole mount retinas that enables to identify ON-, OFF- and ON-OFF-types of GCs according to arborization of their dendrites in the inner plexiform layer, we further demonstrated that NPRs were expressed in these major types of GCs.
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