A presumed case of phantom limb pain treated successfully with duloxetine and pregabalin.

Gen Hosp Psychiatry

Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA.

Published: July 2010

Phantom limb pain (PLP) may occur in nearly 80% of amputation patients. Current research has highlighted several changes that occur in the nociception pathway post amputation. With this knowledge, novel therapies were found that could decrease PLP. Two such drugs are duloxetine and pregabalin, each effecting unique steps in the nociception pathway. We also review the neurobiology and efficacy of this treatment strategy.

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http://dx.doi.org/10.1016/j.genhosppsych.2009.05.012DOI Listing

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