Buffered lidocaine has been recently recommended for local anesthesia, as there is less pain on injection of the buffered solution. Reduced pain on injection of lidocaine and epinephrine buffered to a neutral pH was confirmed in 20 subjects (P less than .01). Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at 25 degrees C. Buffered epinephrine fell to 1.34% of its initial concentration under similar conditions. Buffered lidocaine and epinephrine maintained 94.54% and 82.04%, respectively, of their initial concentrations after 4 weeks when refrigerated at 0-4 degrees C. Both lidocaine and epinephrine maintained greater than 90% concentration 2 weeks after buffering when stored at 0-4 degrees C. This permits batch buffering of lidocaine with epinephrine and storage for periods up to 2 weeks when properly refrigerated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1524-4725.1991.tb03975.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adrenaline Dilution in Dental Local Anesthetic Cartridges: A Practical Method Using the Inner Needle of Intravenous Catheter.
Cureus
December 2024
Division of Dental Anesthesiology, Graduate School of Medicine and Dental Sciences, Niigata University, Niigata, JPN.
Local anesthesia is a routine medical procedure for dentists. To achieve the desired anesthetic effect of lidocaine and favorable hemostatic effects by adrenaline, the combination of 2% lidocaine + 1:80,000 adrenaline is commonly used, including in dental patients with underlying diseases for whom adrenaline in local anesthetics is problematic due to its vasoconstrictive effects, as the adrenaline concentration in dental local anesthetic cartridges in Japan is commercially set at 1:80,000. To reduce the effect of adrenaline on the cardiovascular system, adrenaline is sometimes diluted in dental local anesthetic cartridges.
View Article and Find Full Text PDFA Clinical Comparative Study of Dexmedetomidine, Dexamethasone, and Clonidine as Adjuvants to Local Anesthetics in Supraclavicular Brachial Plexus Blocks.
Cureus
December 2024
Anaesthesiology, Gajra Raja Medical College, Jaya Arogya Group of Hospitals, Gwalior, IND.
Introduction: The brachial plexus block is one of the peripheral blocks, beneath which the majority of upper limb surgical procedures are carried out. During upper limb surgery, a supraclavicular nerve block is an excellent substitute for general anesthesia.
Aim: This is a clinical comparative study of dexmedetomidine, dexamethasone, and clonidine as adjuvants to local anesthetics in supraclavicular brachial plexus block.
Effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve block: A randomized clinical trial.
Dent Res J (Isfahan)
November 2024
School of Dental Medicine, Boston University Henry. M. Goldman, Boston, Massachusetts, USA.
Background: No consensus has been reached on the effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve (IAN) block. This study aimed to assess the effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful IAN block.
Materials And Methods: This double-blind randomized controlled clinical trial was conducted on 45 patients with irreversible pulpitis.
Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report.
JA Clin Rep
December 2024
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background: Local anesthetic systemic toxicity (LAST) is a rare but potentially life-threatening complication. Under general anesthesia, neurological signs are often masked, delaying diagnosis and increasing the risk of sudden cardiovascular collapse. Therefore, early detection methods are critically needed.
View Article and Find Full Text PDFEffectiveness of Lidocaine with Epinephrine Irrigation in Reducing Acute Pain from Surgical Removal of Mesioangular-Impacted Third Molars.
Dent J (Basel)
December 2024
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Background: Anesthetic irrigation is an effective treatment for postoperative pain suppression in patients after molar extraction, but exerts a short period of extraction. The study aimed to evaluate the effect of lidocaine with epinephrine irrigation on acute pain relief in healthy volunteers with inferior alveolar nerve block (IANB) injection for the surgical removal of mesioangular (MA)-impacted third molars.
Methods: A total of 28 patients (56 samples) with bilateral MA-impacted third molars were recruited.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!