4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA, Compound I) was discovered as the first boronic acid-based class D beta-lactamase inhibitor. It exhibited an IC(50) of 5.6 microM against OXA-40. The compound also inhibited class A and C beta-lactamases with sub to low microM IC(50), and synergized with imipenem against Acinetobacter baumannii.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2010.02.065 | DOI Listing |
Publication Analysis
Top Keywords
sulfonylaminomethyl boronic
8
boronic acid
8
beta-lactamase inhibitor
8
47-dichloro benzothien-2-yl
4
benzothien-2-yl sulfonylaminomethyl
4
boronic
4
acid boronic
4
boronic acid-derived
4
acid-derived beta-lactamase
4
inhibitor class
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!