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Radiation-Therapy Related Salivary Dysfunction.
Semin Radiat Oncol
April 2025
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI.; University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI.. Electronic address:
Radiation-induced xerostomia (RIX) is a common and debilitating side effect of head and neck cancer radiotherapy, significantly impacting patients' quality of life. This review comprehensively summarizes the current understanding of RIX, encompassing its clinical quantification, underlying pathophysiology, and established and emerging treatment modalities. We explore various objective and subjective measures used to quantify salivary flow and assess the severity of xerostomia in clinical settings.
View Article and Find Full Text PDFFunctional analyses of the salivary protein SaE23 in Sitobion avenae.
Int J Biol Macromol
March 2025
Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China; Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
To counteract host plant defenses, aphids secrete salivary effectors during feeding. Exact functional roles of many salivary effectors in Sitobion avenae (Fabricius), are still elusive. Here, we cloned a salivary glutathione peroxidase (GPx) coding gene (i.
View Article and Find Full Text PDFCharacterization of Dynamic Adaptation to Stressors using Multi-System Stimulus-Response Data: The Study of Physical Resilience in Aging Pilot.
J Gerontol A Biol Sci Med Sci
March 2025
Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD.
Resilience to stressors has emerged as a major gerontological concept aiming to promote more positive outcomes for older adults. Achieving this aim relies on determining mechanisms underlying capacity to respond resiliently. This paper seeks proof of principle for the hypothesis that physical aspects of said capacity are rooted in the fitness of one's physiology governing stress response, conceptualized as a dynamical system.
View Article and Find Full Text PDFTick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection.
Sci Rep
March 2025
Institute for Game and Wildlife Research, SaBio, IREC-CSIC-UCLM-JCCM, Ronda de Toledo 12, 13005 Ciudad Real, Ciudad Real, Spain.
The alpha-Gal syndrome (AGS) evolved as a catastrophic selection associated with anti-α-Gal IgM/IgG protective response against pathogen infection and tick-borne food allergy caused by IgE-type antibodies against this glycan present in glycoproteins and glycolipids from mammalian meat and derived products. The immune response to α-Gal is modulated by tick salivary proteins with and without α-Gal modifications in combination with tick saliva non-protein fraction. Herein, we characterized the role of tick salivary proteins, metalloprotease and allergen-like p23 in AGS and protection against tuberculosis in the AGS zebrafish animal model.
View Article and Find Full Text PDFDNA Salivary Methylation Levels of the ACE2 Promoter Are Not Related to ACE2 ( and ), TMPRSS2 ( and ) and ACE1 Polymorphisms in COVID-19 Survivors with Post-COVID-19 Condition.
Int J Mol Sci
February 2025
Center for Neuroplasticity and Pain (CNAP), Sensory-Motor Interaction (SMI) Center, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, DK-9220 Aalborg, Denmark.
Genetics and epigenetics are mechanisms proposed for explaining post-COVID-19 condition. This secondary analysis aimed to investigate if DNA methylation levels of the ACE2 promoter are different depending on the genotype of five COVID-19-related polymorphisms in individuals who had been previously hospitalized due to SARS-CoV-2 infection. We collected non-stimulated saliva samples from 279 (48.
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