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A stumbling block in pancreatic cancer treatment: drug resistance signaling networks.
Front Cell Dev Biol
January 2025
Department of General Surgery, Pancreas and Biliary Center, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer. Pancreatic cancer (PC) is a highly fatal cancer with increasing incidence and low five-year survival rates. Currently, there are several therapies that target cell signaling networks in PC.
View Article and Find Full Text PDFUnravelling Factors Shaping International Students' Learning and Mental Wellbeing During the COVID-19 Pandemic: An Integrative Review.
Int J Environ Res Public Health
December 2024
School of Nursing & Midwifery, University of Southern Queensland, Ipswich 4350, Australia.
The international tertiary education sector was significantly affected by the COVID-19 pandemic due to the risk of negative learning and psychosocial experiences. Most international students who remained in the host countries demonstrated admirable resilience and adaptability during those challenging times. An integrative review of factors shaping international students' learning and mental wellbeing during the COVID-19 pandemic was conducted.
View Article and Find Full Text PDFExperienced Versus Perpetrated Intimate Partner Violence and Psychological Maladjustment: The Role of Adaptive and Avoidant Coping.
Int J Environ Res Public Health
December 2024
School of Social Work, University of Texas at Arlington, Arlington, TX 76019, USA.
The present questionnaire study explores the relationship between intimate partner violence (IPV), coping strategies, and psychological maladjustment for both female and male college students, as well as considering the effects of perpetrated IPV. College students are at risk for experiencing and perpetrating IPV, and coping skills may act as important risk and protective factors. In total, 333 (247 women, 86 men) undergraduate college students completed an online survey for research participation credit.
View Article and Find Full Text PDFMaternal Prepregnancy Obesity and Offspring Intelligence Quotient at 5 Years: A Multicohort Analysis.
Paediatr Perinat Epidemiol
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Background: The relationship between maternal obesity and childhood cognitive development remains unclear. Prior studies did not adjust for important confounders, and preterm infants are a developmentally distinct group that remains scarcely examined.
Objectives: To determine whether maternal prepregnancy body mass index (BMI) is associated with offspring intelligence quotient (IQ) up to 5 years and whether this relationship varies with gestational age.
The prevalence and profiles of adverse childhood experiences and their associations with adult mental health outcomes in China: a cross-sectional study.
Lancet Reg Health West Pac
December 2024
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100091, China.
Background: Adverse childhood experiences (ACEs) are common and associated with mental disorders. However, the prevalence and co-occurrence of ACEs and their association with mental health outcomes among Chinese adults have not been well demonstrated.
Methods: China Mental Health Survey, a cross-sectional nationally representative survey consisting of 28,140 adults, was conducted from July 2013 to March 2015.
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