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Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis.
Cells
January 2025
Department of Rheumatology & Clinical Immunology, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation leading to joint damage and systemic complications. Angiogenesis promotes inflammation and contributes to RA progression. This study evaluated potential anti-angiogenic effects of several compounds including small-molecule kinase inhibitors, such as sunitinib (pan-kinase inhibitor), tofacitinib (JAK-inhibitor), NIKi (NF-κB-inducing kinase inhibitor), and the integrin-targeting peptide fluciclatide, using a scratch assay and 3D spheroid-based models of angiogenesis.
View Article and Find Full Text PDFEffects of a 10-week athletic performance program on match performance variables in male professional football players.
Front Sports Act Living
January 2025
Sports Science Research Studies, Rey Juan Carlos University, Fuenlabrada, Madrid, Spain.
Introduction: The aim of this study was to evaluate the effect of an Athletic Performance Program (APP), implemented as a complement to the usual training routines of a professional football team, on match performance variables in professional football players. The APP was designed to target mobility, stability, strength, multidirectional and sprint skills, which are critical for performance during competitive matches.
Methods: A prospective quasi-experimental study was conducted over three consecutive seasons.
Use of climate smart agriculture technologies in West Africa peri-urban Sahel in Niger.
Sci Rep
January 2025
Department of Biology, Faculty of Sciences and Techniques (FST), Dan Dicko Dankoulodo University of Maradi, Maradi, Niger.
Climate change affects peri-urban agricultural systems. However, most studies on Climate-Smart Agriculture (CSA) often focused on climate-smart villages in the Sahel region. This study investigated peri-urban farming systems in West African Sahel cities.
View Article and Find Full Text PDFOne Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens.
Diabetes Care
January 2025
Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
Microdose Cocktail Study Reveals the Activity and Key Influencing Factors of OATP1B, P-Gp, BCRP, and CYP3A in End-Stage Renal Disease Patients.
Clin Pharmacol Ther
January 2025
Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China.
OATP1B, P-gp, BCRP, and CYP3A are the most contributing drug-metabolizing enzymes or transporters (DMETs) for commonly prescribed medication. Their activities may change in end-stage renal disease (ESRD) patients with large inter-individual variabilities (IIVs), leading to altered substrate drug exposure and ultimately elevated safety risk. However, the changing extent and indictive influencing factors are not quantified so far.
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