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Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice.
Aging Cell
January 2025
Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China.
The current mechanism by which aging reduces salivary secretion is unknown. This study investigates the mechanism of aging-related submandibular (SMG) dysfunction and evaluates the therapeutic potential of dental pulp stem cell-derived exosomes (DPSC-exos). We found that the stimulated salivary flow rate was significantly reduced in naturally aging and D-galactose-induced aging mice (D-gal mice) compared to control mice.
View Article and Find Full Text PDFDouble or nothing: Ancient duplications in the amylase locus drove human adaptation.
Cell Genom
January 2025
Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Electronic address:
Salivary and pancreatic amylase are encoded by AMY1 and AMY2, respectively, which are located within a single genomic locus that has undergone substantial structural variation, resulting in varying gene copy numbers across species. Using optical genome mapping and long-read sequencing, Yilmaz, Karageorgiou, Kim, et al. achieved nucleotide-level resolution of this locus across different human populations, offering new insights into how copy number variation contributes to human adaptation.
View Article and Find Full Text PDFOral microbiome dysbiosis is associated with precancerous lesions and disorders of upper gastrointestinal tract: A population-based study.
Am J Gastroenterol
December 2024
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Background And Aims: Oral microbiota may contribute to the development of upper gastrointestinal (UGI) disorders. We aimed to study the association between the microbiome of saliva, subgingival and buccal mucosa, and UGI disorders, particularly precancerous lesions. We also aimed to determine which oral site might serve as the most effective biomarker for UGI disorders.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Background: Approximately 6.7 million people in the US are diagnosed with an Alzheimer's disease (AD), with greater incidence in women and minorities. Approximately 11 million family members provide uncompensated care to their family members with dementia, with more than 60% reporting high or very high levels of stress, a condition associated with increased risk for AD.
View Article and Find Full Text PDFDenture biofilm increases respiratory diseases in the elderly. A mini-review.
Am J Dent
December 2024
Department of Prosthodontics and Periodontics, University of São Paulo (USP), Bauru, Brazil,
Purpose: This mini-review discusses the clinical implication of respiratory pathogens in the biofilm on acrylic resin removable dentures in the elderly.
Methods: A search was conducted using the keywords: "dentures", " acrylic resin", "biofilm", "pneumonia", "elderly", "respiratory pathogens", and "respiratory diseases" in databases PubMed/Medline, Lilacs, SciELO and textbooks between 1999 and 2024.
Results: The elderly are more susceptible to chronic diseases and/or life-threatening infections because of senescence itself and functional and degenerative alterations.
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