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Re-evaluating Presumptive Treatment with Doxycycline/ Azithromycin in Children With Acute Febrile Illness in a Scrub Typhus Endemic Region: A Cross-Sectional Study.
Indian Pediatr
January 2025
ICMR Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India. Correspondence to: Dr Manoj Murhekar, Director-in-Charge, ICMR-Regional Medical Research Centre, Gorakhpur, Uttar Pradesh, India 273013.
Objective: To estimate the proportion of children with acute febrile illness (AFI) attending the peripheral health facilities in Gorakhpur, Uttar Pradesh, India, due to Orientia tsutsugamushi (Ots) and re-evaluate the strategy of presumptive administration of doxycycline/azithromycin (PDA) to patients with AFI.
Methods: Children aged 2-18 years with AFI attending 16 peripheral health facilities in Gorakhpur, Uttar Pradesh, were enrolled in September 2023. Blood samples were tested for O.
The Maturation of the International Health Crisis Response: The Polish Typhus Epidemic of 1916-1923 Compared to the African Ebola Virus Disease Epidemic of 2013-2016: Part I, the Polish Epidemic.
Epidemiologia (Basel)
December 2024
Division of Infectious Diseases, Medical Service, South Texas Veterans Healthcare System, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA.
Poland suffered an epidemic of louse-borne typhus from 1916-1923, with 400,000 cases and more than 130,000 deaths. The causative factors were depressed economic conditions and a refugee crisis that engulfed Poland after World War I. The recognition of the epidemic in 1919 stimulated the creation of the League of Red Cross Societies (LRCS).
View Article and Find Full Text PDFPredicting Leptospirosis Using Baseline Laboratory Tests and Geospatial Mapping of Acute Febrile Illness Cases Through Machine Learning-Based Algorithm.
Cureus
November 2024
Pharmacology, All India Institute of Medical Sciences, Kalyani, IND.
Introduction Leptospirosis is a zoonotic infection caused by bacteria, which is reemerging in various regions and often poses a diagnostic challenge due to its nonspecific symptoms. While most infections are mild, severe cases occur in 5-10% of patients and are associated with high mortality, especially in areas with poor sanitation and urbanization. This study aims to investigate the association of specific parameters with leptospirosis diagnosis using a machine learning model and geographic mapping tools to identify spatial patterns and high-risk areas for the disease.
View Article and Find Full Text PDFTick-, flea- and mite-borne pathogens and associated diseases of public health importance in Bangladesh: a review.
Infect Med (Beijing)
December 2024
Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA 30458, USA.
Background: This scoping review provides a baseline summary of the current records of the ticks, fleas, and mites of public health importance that are present in Bangladesh. It summarizes their geographic distributions and reports the levels of their infestation of livestock, pets, wildlife, and humans, and the clinical and epidemiological studies pertinent to these vectors and their pathogens.
Methods: Sixty-one articles were identified in a literature search, including 43 published since 2011.
The Association of Lipid Abnormalities with Complications in Severe Scrub Typhus.
J Assoc Physicians India
December 2024
Professor, Department of Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India, Corresponding Author.
Aim: To study abnormalities of lipids in patients suffering from severe scrub typhus and their relationship with complications.
Methods: This cohort study was conducted in patients of severe scrub typhus [immunoglobulin (IgM) positive by enzyme-linked immunosorbent assay (ELISA)] admitted to our institute from 1 August 2020 through 31 July 2021. The lipid profile was estimated initially at the time of hospitalization.
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