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In vitro dissolution profiles of enteric-coated microsphere/microtablet pancreatin preparations at different pH values.
Aliment Pharmacol Ther
October 1996
Adult Cystic Fibrosis Centre, Leyenburg Hospital, The Hague, The Netherlands.
Objectives: Enteric-coated microsphere/microtablet pancreatin should stay intact in the stomach and dissolve promptly on entering the duodenum. Postprandial intraluminal pH in the distal duodenum is 5.75 and is lower in exocrine pancreatic insufficiency.
View Article and Find Full Text PDFTwenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption.
J Pediatr Gastroenterol Nutr
July 1996
Department of Paediatrics, University of Sheffield, England.
Overt steatorrhoea remains a problem for some patients with cystic fibrosis (CF) despite supraphysiological dosages of pancreatic enzymes. As pancreatin release and enzyme function is influenced by duodenal pH, we have used 24-h ambulatory pH measurements to assess the extent and duration of postprandial hyperacidity. Readings were obtained from the stomach and proximal duodenum in 16 CF patients (aged 6 months to 12 years) using a dual-channel antimony electrode.
View Article and Find Full Text PDFTherapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis.
Pancreas
July 1992
Department of Medicine, Raigmore Hospital, Inverness, Scotland, U.K.
We investigated the therapeutic potential of an acid-resistant fungal lipase prepared from Aspergillus niger. We first demonstrated in vitro that it had a wide pH optimum of 2.5-5.
View Article and Find Full Text PDFCystic fibrosis patients have an increased requirement for calories and probably for all the major nutrients. The newer, enteric-coated granular preparations of pancreatic enzyme are more effective than preceding preparations and should permit a normal fat intake. Recent work has emphasized the interdependence of respiratory disease and nutrition.
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