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A rare case report of bilateral Purtscher-like retinopathy in juvenile dermatomyositis.
GMS Ophthalmol Cases
May 2024
Department of Pathology, Christian Medical College, Vellore, India.
Purpose: To report a rare case of bilateral Purtscher-like retinopathy (PLR) in a young adult diagnosed with dermatomyositis.
Method: A case report with multi-modal imaging.
Result: A 17-year-old male presented with subacute marked diminution of vision along with arthralgia, weakness of all four limbs and development of multiple rashes around body.
Intravenous cyclophosphamide therapy for patients with severe ocular inflammatory diseases who failed other immunomodulatory therapies.
J Ophthalmic Inflamm Infect
March 2024
Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Article Synopsis
- Ocular inflammatory diseases like scleritis and uveitis are treated with immunomodulatory therapies (IMTs) to reduce reliance on steroids, using both conventional and biologic agents, including cyclophosphamide (CP), an effective but potentially harmful treatment option.
- A study reviewed the medical records of 1295 patients at Stanford’s Uveitis Clinic from 2017 to 2022, focusing on 7 patients who received CP therapy for severe ocular inflammatory diseases that didn’t respond to other IMTs.
- The average age of these patients was 61.6 years, with various underlying conditions, and after a mean follow-up of 34.4 months on CP therapy,
Bilateral Occlusive Retinal Vasculitis in a Patient with Dermatomyositis.
Middle East Afr J Ophthalmol
July 2023
Division of Ophthalmology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
A 48-year-old woman with a history of dermatomyositis (DMS) presented with 2 weeks of worsening myalgias, weakness, and diffuse edema following cessation of her systemic immunosuppression and subsequently developed severe bilateral vision loss consistent with bilateral frosted branch angiitis. Multimodal imaging was performed, and the patient was successfully treated with pulse-dose steroids and intravenous immunoglobulin, as well as intravitreal aflibercept. Ophthalmic involvement of DMS is typically limited to episcleritis, conjunctivitis, and uveitis.
View Article and Find Full Text PDFRetinal microvascular and microstructural alterations in the diagnosis of dermatomyositis: a new approach.
Front Med (Lausanne)
May 2023
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Purpose: To study the relationship between fundus alterations, including retinal thickness and microvascular changes, and dermatomyositis (DM) using optical coherence tomography angiography (OCTA).
Methods: A total of 16 patients with DM (32 eyes) and 16 healthy controls (HCs; 32 eyes) participated in this study. Based on the Early Treatment Diabetic Retinopathy Study subzones, OCTA fundus data were divided into different layers and regions for comparison.
What to expect from paraneoplastic syndromes of the nervous system in uterine cancer: A review of the literature.
Gynecol Oncol Rep
February 2023
Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
Neurological paraneoplastic syndromes are a rare subgroup of diseases commonly related to neuroendocrine tumors. However, they have been associated with uterine malignancies (sarcomas, endometrial carcinomas, and neuroendocrine cancers). Their presentation often correlates with a cancer diagnosis or cancer recurrence underlining their clinical significance.
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