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Effects of maternal antiretroviral drugs in pregnancy on haematological and biochemical parameters in neonates exposed in utero.
Int J STD AIDS
March 2025
Paediatric Department, Luton & Dunstable University Hospital, Luton, UK.
BackgroundThe British HIV Association recommends the use of antiretroviral therapy (ART) in all pregnant women living with HIV to protect against mother to child transmission. ART may cause side effects including anaemia, macrocytosis and neutropenia.MethodsIn a retrospective study conducted in a District General Hospital in the United Kingdom in 2024 using a historical cohort, we compared neonatal haemoglobin, mean corpuscular volume (MCV), reticulocyte, neutrophil and lymphocyte counts, alanine aminotransferase and bilirubin levels on the first day of life and at 6 weeks of life in children born to mothers who at delivery were on azidothymidine (AZT) containing ART regimes with newborns not exposed to those regimes.
View Article and Find Full Text PDFPhytochemical, In Silico, In Vitro, and In Vivo Research on Piptadeniastrum africanum (Fabaceae) Unveiling Anti-Stereotypic, Anxiolytic, and Analgesic Effects in a Sodium Valproate-Induced Autistic Disorders Model.
Brain Behav
March 2025
Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Objective: Individuals with autistic spectrum disorders (ASD) primarily exhibit deficits in communication and social interaction, along with repetitive behaviors and restricted interests. This disorder is often associated with anxiety, nociceptive disorders, and pain. While medical treatment generally focuses on treating the symptoms rather than addressing the underlying causes, traditional medicine is sometimes used as an alternative.
View Article and Find Full Text PDFA population-based cohort study of perinatal mental illness following traumatic brain injury.
Epidemiol Psychiatr Sci
March 2025
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Aims: To examine the risk of perinatal mental illness, including new diagnoses and recurrent use of mental healthcare, comparing women with and without traumatic brain injury (TBI), and to identify injury-related factors associated with these outcomes among women with TBI.
Methods: We conducted a population-based cohort study in Ontario, Canada, of all obstetrical deliveries to women in 2012-2021, excluding those with mental healthcare use in the year before conception. The cohort was stratified into women with no remote mental illness history (to identify new mental illness diagnoses between conception and 365 days postpartum) and those with a remote mental illness history (to identify recurrent illnesses).
Belonging: a meta-theme analysis of women's community-making in group antenatal and postnatal care.
Front Public Health
March 2025
Centre for Maternal and Child Health, City St. George's, University of London, London, United Kingdom.
Health care systems are social institutions simulating microcosms of wider societies where unequal distribution of power and resources translate into inequities in health outcomes, experiences and access to services. Growing research on participatory women's groups positively highlights the influence of group-based care on health and wellbeing for women, their infants, families and wider communities across different countries. With similarities in ethos and philosophies, group care combines relational, group-based facilitation and clinical care, uniquely offering an opportunity to examine the intersections of health and social care.
View Article and Find Full Text PDFHigh sperm DNA stainability might not be an accurate predictive indicator of male fertility and assisted reproductive technology outcomes.
Front Endocrinol (Lausanne)
March 2025
Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Background: The clinical need for assisted reproduction continued to increase, so did the need for predictive markers of assisted reproductive technology (ART) outcomes. Among all the markers, sperm DNA integrity was paid more and more attention in the assessment of male fertility in recent years, but its clinical value remains still in doubt.
Methods: We conducted a retrospective cohort study.
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