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Malaria Tropica: An Autopsy Case Report With a Discussion on the Presence of Malaria in Bulgaria.
Cureus
June 2024
General and Clinical Pathology, Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.
Malaria is an infectious disease caused by several types of parasitic plasmodia and transmitted to humans through Anopheles mosquitoes. The disease has long been widespread and has caused a significant number of deaths and decreased life quality from sequelae worldwide. As understanding of the disease increased immensely at the beginning of the 20th century, eradication plans were implemented to decrease disease transmission.
View Article and Find Full Text PDFPhysiopathology and clinical management of blackwater fever: a scoping review.
Clin Microbiol Infect
January 2024
Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella (Verona), Italy.
Background: Blackwater fever (BWF) is a severe syndrome occurring in patients with malaria upon antimalarial treatment, characterized by massive intravascular haemolysis and haemoglobinuria. BWF is a neglected condition and management recommendations are unavailable.
Objectives: We performed a scoping review to appraise available data on clinical picture, treatment and physiopathology of BWF, which could guide rationally its clinical management.
PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria.
BMJ Open
July 2023
Clinical trials department, Mbale Clinical Research Institute, Mbale, Uganda.
Background: Acute kidney injury (AKI) has in the past been considered a rare complication of malaria in children living in high-transmission settings. More recently, however, a growing number of paediatric case series of AKI in severe malaria studies in African children have been published (Artesunate vs Quinine in the Treatment of Severe Malaria in African children and Fluids Expansion as Supportive Therapy trials). The Paracetamol for Acute Renal Injury in Severe Malaria Trial (PARIST) therefore, aims to assess feasibility, safety and determine the effective dose of paracetamol, which attenuates nephrotoxicity of haemoproteins, red-cell free haemoglobin and myoglobin in children with haemoglobinuric severe malaria.
View Article and Find Full Text PDFSevere Malaria with a Rare Tetrad of Blackwater Fever, Acute Renal Failure, Disseminated Intravascular Coagulopathy, and Acute Acalculous Cholecystitis.
Case Rep Infect Dis
May 2023
Reading Hospital Tower Health, West Reading, PA, USA.
Article Synopsis
- * A case was reported of a healthy 24-year-old male who developed classic BWF after traveling to Sierra Leone, tested positive for malaria, and required intensive treatment, including plasmapheresis due to renal failure.
- * Malaria remains a serious public health issue globally, and healthcare providers must be vigilant in diagnosing it, especially in travelers returning from areas where malaria is common.
Causes of blackwater fever, a complication of malaria treatment, are not completely clear, and immune mechanisms might be involved. Clinical management is not standardized. We describe an episode of blackwater fever in a nonimmune 12-year-old girl in Italy who was treated with steroids, resulting in a rapid clinical resolution.
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