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Machine-Learning Mental-Fatigue-Measuring μm-Thick Elastic Epidermal Electronics (MMMEEE).
Nano Lett
December 2024
Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States.
Electrophysiological (EP) signals are key biomarkers for monitoring mental fatigue (MF) and general health, but state-of-the-art wearable EP-based MF monitoring systems are bulky and require user-specific, labeled data. Ultrathin epidermal electrodes with high performance are ideal for constructing imperceptive EP sensing systems; however, the lack of a simple and scalable fabrication delays their application in MF recognition. Here, we report a facile, scalable printing-welding-transferring strategy (PWT) for printing μm-thickness micropatterned silver nanowires (AgNWs)/sticky polydimethylsiloxane, welding the AgNWs via plasmonic effect, and transferring the electrode to skin as tattoos.
View Article and Find Full Text PDFPlug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging.
Mol Ther Nucleic Acids
September 2024
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
In cancer molecular imaging, selecting binders with high specificity and affinity for biomarkers is paramount for achieving high-contrast imaging within clinical time frames. Nanobodies have emerged as potent candidates, surpassing antibodies in pre-clinical imaging due to their convenient production, rapid renal clearance, and deeper tissue penetration. Multimerization of nanobodies is a popular strategy to enhance their affinity and pharmacokinetics; however, traditional methods are laborious and may yield heterogeneous products.
View Article and Find Full Text PDFFGF7 and FGF10 Promote Fate Transition of Human Epidermal Cell-derived Organoids to an Eccrine Gland Phenotype.
Int J Biol Sci
September 2024
Department of Burns and Plastic Surgery, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong Province, China.
Reconstruction of hair follicles (HFs) and eccrine sweat glands (ESGs) is essential for functional skin regeneration. In skin reconstruction research, we found that foreskin-derived epidermal cells reconstructed HF organoids unidirectionally, but not ESG organoids. To investigate key genes and pathways influencing the fate of ESG and HF, a transcriptome profiling of ESG placode-containing skin and HF placode-containing skin was employed, and key DEGs were identified and validated by RT-qPCR and immunofluorescence staining in mice and rats.
View Article and Find Full Text PDFFamilial Reactive Perforating Collagenosis with Adolescence-Onset: A Rare Case Report and Literature Review.
Clin Cosmet Investig Dermatol
August 2024
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Article Synopsis
- - Familial Reactive Perforating Collagenosis (FRPC) is a rare, benign skin condition primarily seen in young children, with fewer than 50 documented cases, and its causes and treatments remain unclear.
- - A case study of a 20-year-old male from Indonesia showed multiple skin papules across his body for over 7 years, and similar symptoms were present in his family.
- - The patient was successfully treated with a topical corticosteroid, desoximetasone, leading to significant improvement in skin lesions, suggesting corticosteroids could be a viable treatment for FRPC.
A Case of Noonan Syndrome and Kyrle's Disease: Coincidence or Causality?
Acta Dermatovenerol Croat
March 2024
Marco Brusasco, MD, University of Parma, Via Gramsci 14, Parma, Italy;
Article Synopsis
- A 39-year-old woman with Noonan Syndrome and a RAF1 mutation presented with itchy lesions on her limbs that developed two months prior, characterized by multiple dome-shaped papules.
- Blood tests showed no abnormalities, but a skin biopsy revealed features consistent with Kyrle's disease, a type of perforating dermatosis.
- The patient was treated with narrowband UVB phototherapy, resulting in complete resolution of symptoms despite leaving residual atrophic scars.
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