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Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.
Commun Biol
January 2025
Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Intracranial electrical kilohertz stimulation has recently been shown to achieve similar therapeutic benefit as conventional frequencies around 140 Hz. However, it is unknown how kilohertz stimulation influences neural activity in the mammalian brain. Using cellular calcium imaging in awake mice, we demonstrate that intracranial stimulation at 1 kHz evokes robust responses in many individual neurons, comparable to those induced by conventional 40 and 140 Hz stimulation in both the hippocampus and sensorimotor cortex.
View Article and Find Full Text PDFOcean warming and acidification alter calcification and innate immune system gene expression in juvenile American lobsters, Homarus americanus.
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
School for the Environment, University of Massachusetts Boston, Boston, MA 02125, USA; Presidents Office, Ursinus College, Collegeville, PA 19426, USA.
Article Synopsis
- The Gulf of Maine is facing severe ocean warming and acidification, impacting the American lobster, with limited research on how these stressors interact specifically on gene expression.
- Two aquarium experiments were conducted that simulated future ocean conditions to assess the effects of these stressors on juvenile lobsters' gene expression, revealing complex responses in genes related to calcification and immune function.
- Findings indicate that elevated temperatures significantly affect gene expression, potentially leading to impaired normal development and increased vulnerability to disease due to these combined stressors.
Regulation of monocyte apoptosis and DNA extrusion in monocyte extracellular traps by PSGL-1: Relevance in systemic lupus erythematosus.
Transl Res
December 2024
Immunology Department, Fundación de Investigación Biomédica (FIB), Instituto de Investigación Sanitaria-Princesa (IIS-Princesa), Hospital de la Princesa, 28006, Madrid, Spain. Electronic address:
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by severe organ damage and lacking curative treatment. While various immune cell types, especially dysfunctional B and T cells and neutrophils, have been related with disease pathogenesis, limited research has focused on the role of monocytes in SLE. Increased DNA extracellular traps, apoptosis and necrosis have been related to lupus pathogenesis.
View Article and Find Full Text PDFPSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study.
Front Immunol
August 2024
Immunology Department, Fundacion para la Investigacion Biomedica (FIB)-Hospital Universitario de La Princesa, Instituto de Investigacion Sanitaria (IIS)-Princesa, Madrid, Spain.
Background: Early diagnosis and treatment of Systemic lupus erythematosus (SLE) and Systemic sclerosis (SSc) present significant challenges for clinicians. Although various studies have observed changes in serum levels of selectins between healthy donors and patients with autoimmune diseases, including SLE and SSc, their potential as biomarkers has not been thoroughly explored. We aimed to investigate serum profiles of PSGL-1 (sPSGL-1), ADAM8 (sADAM8) and P-, E- and L-selectins (sP-, sE- and sL-selectins) in defined SLE and SSc patient cohorts to identify disease-associated molecular patterns.
View Article and Find Full Text PDFVariations in threshold values for border zone and dense scar produce significant changes in scar parameters obtained by ADAS-3D.
Heart Rhythm
January 2025
Department of Cardiology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Bioheart-Cardiovascular Diseases Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:
Background: ADAS-3D software elaborates cardiac magnetic resonance (CMR) images to obtain a quantitative evaluation of dense scar and border zone (BZ), including BZ channels, which can be useful for ventricular tachycardia ablation and risk stratification. However, most prior reports with ADAS-3D used flexible thresholds (60% ± 5% and 40% ± 5% of maximum pixel signal intensity) to define dense scar and BZ. The impact of such variations of the threshold values on the measurements obtained with ADAS-3D is unknown.
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