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Nanoparticle-Doped Antibacterial and Antifungal Coatings.
Polymers (Basel)
January 2025
Department of Chemical Engineering, Dr B R Ambedkar National Institute of Technology, Jalandhar 144011, Punjab, India.
Antimicrobial polymeric coatings rely not only on their surface functionalities but also on nanoparticles (NPs). Antimicrobial coatings gain their properties from the addition of NPs into a polymeric matrix. NPs that have been used include metal-based NPs, metal oxide NPs, carbon-based nanomaterials, and organic NPs.
View Article and Find Full Text PDFInterference of Celastrol with Cell Wall Synthesis and Biofilm Formation in .
Antibiotics (Basel)
January 2025
Departamento de Bioquímica, Microbiología, Biología Celular y Genética, Facultad de Farmacia, Universidad de La Laguna, Avenida Astrofísico Fco Sánchez s/n, 38206 La Laguna, Spain.
: The emergence of antibiotic-resistant bacteria, including , underscores the need for novel antimicrobial agents. Celastrol, a natural compound derived from the plants of the Celastraceae family, has demonstrated promising antibacterial and antibiofilm properties against various pathogens. This study aims to evaluate the antibacterial effects, mechanism of action, and antibiofilm activity of celastrol against , an emerging opportunistic pathogen.
View Article and Find Full Text PDFA dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced and toxicity.
RSC Adv
January 2025
University of Split, Faculty of Science, Department of Chemistry R. Bošković 33 Split Croatia
Quaternary ammonium compounds (QACs) have served as essential antimicrobial agents for nearly a century due to their rapid membrane-disrupting action. However, the emergence of bacterial resistance and environmental concerns have driven interest in alternative designs, such as "soft QACs", which are designed for enhanced biodegradability and reduced resistance potential. In this study, we explored the antibacterial properties and mechanisms of action of our newly synthesized soft QACs containing a labile amide bond within a quinuclidine scaffold.
View Article and Find Full Text PDFCombating Antibiotic-Resistant Bacterial Infection Using Coassembled Dimeric Antimicrobial Peptide-Based Nanofibers.
ACS Nano
January 2025
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, P. R. China.
The emergence of multidrug-resistant (MDR) pathogens, coupled with the limited effectiveness of existing antibiotics in eradicating biofilms, presents a significant threat to global health care. This critical situation underscores the urgent need for the discovery and development of antimicrobial agents. Recently, peptide-derived antimicrobial nanomaterials have shown promise in combating such infections.
View Article and Find Full Text PDFPro-Health Potential of Fruit Vinegars and Oxymels in Various Experimental Models.
Int J Mol Sci
December 2024
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/3, 90-236 Lodz, Poland.
Fruits are excellent sources of substrate for various fermented products, including fruit vinegars, which are typically produced by submerged fermentation. Some evidence suggests that fruit vinegar consumption can alleviate certain disorders, including hyperlipidemia, inflammation, and hyperglycemia. Fruit vinegars also have bacteriostatic and antihypertensive actions.
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