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Mutations Contribute to Infantile Epileptic Spasm Syndrome and Neuroinflammation.
Int J Med Sci
July 2024
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
There are more than 70 million people worldwide living with epilepsy, with most experiencing the onset of epilepsy in childhood. Despite the availability of more than 20 anti-seizure medications, approximately 30% of epilepsy patients continue to experience unsatisfactory treatment outcomes. This situation places a heavy burden on patients' families and society.
View Article and Find Full Text PDFDiscordant electroencephalogram epileptiform activity and hemispherectomy in children with refractory epilepsy and encephaloclastic lesions: a case series.
Dev Med Child Neurol
March 2022
School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
This is a case series of six children with unilateral cerebral palsy and hemispheric encephaloclastic lesions who were evaluated for epilepsy surgery. Seizure onset was in the neonatal period in three children, at 17 months in two, and at 5 years in one. Their ictal and interictal electroencephalogram (EEG) abnormalities showed paradoxical lateralization to the incorrect/'normal' hemisphere or showed bilateral abnormalities.
View Article and Find Full Text PDFSurgical strategy for refractory epilepsy secondary to porencephaly: ictal SPECT may obviate the need for intracranial electroencephalography. Patient series.
J Neurosurg Case Lessons
May 2021
Pediatrics, National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.
Background: Surgical treatment of intractable epilepsy caused by porencephaly can be difficult because of poorly localizing or lateralizing electroclinical findings. The authors aimed to determine whether noninvasive evaluations are sufficient in these patients.
Observations: Eleven patients were included in this study.
Risk factors and results of hemispherotomy reoperations in children.
Neurosurg Focus
April 2020
1Division of Pediatric Neurosurgery, Ribeirao Preto Medical School; and.
Objective: The goal of this study was to perform an analysis of a single-center experience with hemispherotomy reoperations for refractory hemispheric pediatric epilepsy due to persistence of seizures after initial surgery. The authors also identify possible anatomical and neurophysiological reasons for hemispherotomy failure, as well as risk factors and surgical options for this subgroup of patients.
Methods: A review was performed of the medical records in 18 consecutive cases in which candidates for redo hemispherotomy were treated between 2003 and 2018 at the authors' epilepsy surgery center.
Asymmetry of the bilateral bispectral index in a hemiparetic patient with porencephaly.
J Clin Anesth
August 2019
Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan. Electronic address:
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